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Flashcards in Pathology of tumours Deck (11):
1

Radiolucent with increasing density towards periphery.
Destruction of medullary cavity and adjacent cortex.
May expand into soft tissue.

Giant cell tumour

2

Multinucleated giant cells in a sea of round to oval mononuclear cells

Giant cell tumour

3

Irregular spicules of mineralised bone and osteoid surrounded by osteoblasts

Vascular stroma with pleomorphic spindle cells

Osteoid and woven bone are seen

Osteoblastoma

4

Lobules and fibrous septa. The malignant cell has eosinophilic cytoplasm & prominent vacuoles of mucus push the nuclei to the side.

Chordoma

5

Malignant osteoblasts forming osteoid

Young adults; 60%

Osteosarcoma

6

Osteoid production is essential for diagnosis.

Nuclear atypia, hyperchromasia and a high mitotic rate.

There are three histological variants of conventional osteosarcoma: osteoblastic, chondroblastic, and fibroblastic..

Osteosarcoma

7

Closely packed polygonal cells plus areas of immature chondroid

Chondroblastoma

8

Chicken wire calcification

Chondroblastoma

9

Spherical and well-defined osteolytic foci, sometimes extending into the subarticular bone, joint space or metaphysis

Chondroblastoma

10

Nidus consists of osteoid and woven bone surrounded by osteoblasts.
Central nidus of an osteoid osteoma composed of irregular reactive new bone

Osteoid osteoma

11

Radiolucent nidus surrounded by reactive sclerosis in cortex of bone

Osteoid osteoma