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Flashcards in Vasculitis Deck (25):
1

Treatment of PMR or GCA

Steroids
-If these don't work then question your diagnosis
-PMR (prednisolone 10-15mg)
-GCA (prednisolone 60-100mg usually in divided doses)
Calcium and Vitamin D supplements are necessary to prevent osteoporosis while high dose steroids are being used

2

PMR and GCA differential diagnoses

RA, vasculitis, infection, malignancy

3

Increased frequency of what allele in spondyloarthritis?

HLA-B27

4

Takayasu arteritis
Giant Cell Arteritis

Large vessel

5

PAN
Kawasaki’s
Isolated CNS vasculitis

Medium vessel

6

Churg-Strauss
Wegener’s
Microscopic Polyangiitis
HSP
Essential Cryoglobulinemia
Hypersensitivity vasculitis
Vasculitis 2nd to CTD
Vasculitis 2nd to viral infection

Small vessel

7

PAN

polyarteritis nodosa

8

ANCA positive

Wegeners (90%)
Microscopic Poly angiitis (70%)
Churg-Strauss (50%)
Drug-Induced (Hypersensitivity)

9

ANCA negative

HSP
Cryoglobulinemia

10

Definition of vasculitis

Presence of leukocytes/immune complexes in the vessel wall with reactive damage to mural structures

11

Anti-PR3 antibodies are highly specific for which condition?

GPA (Wegeners)

12

ELISA?

Used to help investigate possible vasculitis
If cANCA is associated with MPO but not PR3 then consider different diagnosis such as non-ANCA associated vasculitis e.g. drug induced
If cANCA positive but doesn't demonstrate PR3 pattern then it is most likely due to the presence of bacterial permeability increasing protein ANCA found in chronic infections e.g. CF, bronchiectasis, subacute bacterial endocarditis, ulcerative colitis

13

Which medications will cause a large titre of MPO antibodies?

Hydralazine, allopurinol and propylthiouracil can cause a large titre of MPO antibodies

14

Give an example of a pauci-immune vasculitis

Wegeners (pauci-immune = neutrophils found in vessels)

15

Give an example of a primary immune vaculitis

HSP

16

How do you assess vasculitis?

BVAS
(Birmingham vasculitis assessment score)

17

BVAS (Birmingham vasculitis assessment score)

Used to assess vasculitis

18

Pauci-immune?

Nuetrophils in blood vessel
e.g. Wegeners

19

Immune vasculitis?

Immune complexes in blood vessel

20

Treatment for localised/early systemic vasculitis

Methotrexate and steroids

21

First line and alternative treatment for general/systemic vasculitis?

1st line = cyclophosphamide + steroids
Alternative = Rituximab and steroids

22

Treatment for refractory vasculitis?

IV immunoglobulin
Rituximab

23

Causes of death in people with vasculitis?

Infection, cardiovascular disease and cancer

24

cANCA

PR3

25

pANCA

MPO