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Flashcards in Patterns of liver injury Deck (13):
1

evolution of fatty liver disease

Hepatic steatosis, steatohepatitis, fibrosis/cirrhosis, CA (HCC)

2

what is metabolic syndrome

central (around waist) obesity, DM 2, HTN, dyslipidemia

3

What causes macrovesicular fatty liver

nurtritional (obesity, TPN), metabolic (DM, hyperlipidemia), drug-related (EtOH, corticosteroids)

4

what causes microvesicular fatty liver

pregnancy, Reye's syndrome, tetracyclines

5

Lipogranulomas

cause lipoapoptosis. Exposure of non-adipose tissue (heliver) to excess long-chain FAs

6

PPARalpha

becomes defective/overloaded in fatty liver dz.

7

PPAR alpha vs gamma

alpha is signaled when fat comes into system and helps burn fat. Gamma stores fat

8

what pattern of drinking contributes more to liver damage: binge or steady

steady

9

ADH/ALDH2 pathway of alcohol metabolism

EtOH converted by Alcohol dehydrogenase (ADH) to acetaldehyde (toxic) in the cytosol which aldehyde dehydrogenase (ALDH2) then converts to acetate in the mitochondria.

10

Mutations in alcohol metabolism

most asians have mutant ADh that metabolizes EtOH faster resulting in acetaldehyde accumulation. ALDH2 mutation in some groups leads to inactivity and acetaldehyde buildup.

11

CYPs in EtOH metabolism

2E1. Generates ROS which damage hepatocytes and stimulate stellate cells to make collagen

12

three histo features of alcoholic hepatitis

necrosis, Mallory bodies, PMN infiltration

13

two major effects of acetaldehyde on liver

stellate cell activation leading to fibrosis. Steatohepatitis by altering metabolism and leading to hepatocyte death