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Flashcards in GI motility disorders Deck (10):

histopathology of achalasia

degeneration of myenteric NO (inhibitory) neurons due to inflammation


what can mimic GI dysmotility both radiographically and manometrically

mechanical obstruction (must rule out!)


three main causes of secondary achalasia

psuedoachalasia (Cancer associated), post fundoplication, Chagas


Diabetic gastroparesis: what type of neuropathy? What happens?

autonomic (vagal). Gastric body and antral hypomotility and pylorospasm result in prolongation of emptying times


two motility patterns of small bowel and describe them

Fed pattern- segmenation. Fasting pattern- MMC


three phases of MMC

Phase 1- motor inactivity. Phase 2- intermittent, non propagating contractions. Phase 3- burst of contractions from duodenum to distal ileum


Scleroderma: what type of neuropathy? Where in GI tract? Most common location? What happens when it occurs in small bowel?

myopathic. Any part. Esophageal dysmotility. Absent contractile activity leads to dilation with stacked coin appearance and diverticulae


two main causes of intestinal pseudo-obstruction

post operative ileus. Scleroderma


Ogilvie's Syndrome: what type of neuropathy? when does it occur? Where does it occur? What happens?

autonomic. post-op. hindgut. Colonic distention in absence of mechanical obstruction


Hirschsprung's Disease: how do you get it? what happens? what results?

congenital, failure of neural crest cells giving rise to ENS (esp NO containing neurons) to populate distal digestive tract. Internal anal sphincter won't relax. megacolon