Flashcards in GI pharm Deck (12):
Antacids: which are absorbable and adverse affects? non absorbable? characteristics?
Mg (diarrhea), Al (constipation), Ca (constipation) based.
NaHCO3 (alkalosis) based.
Rapid onset and short duration
H-2RAs: suffix? mechanism? when should they be taken?
-tidine. competitive inhibition. Taken before bedtime (NO EATING afterwards b/c food signal can overcome blockade)
H2RA drug interactions
cimetidine inhibits CYP450 (relevant for phenytoin, warfarin, theophylline b/c of narrow therapeutic window)
PPIs: suffix? mechanism? side effects?
-prazole. Taken up by parietal cell, protonated, excreted, covalent bond with H/K ATPase (body must make new pump to regain secretion).
Slight risk of C. diff
PPI: drug interactions
Omeprazole weakly interacts with phenytoin, warfarin, diazepam, CLOPIDOGREL
What do you use PPIs for?
GERD, as part of H. pylori triple therapy (PPI, clarithromycin, amoxicillin), peptic ulcers (idiopathic, NSAID related), bleeding ulcer
problematic in pts with renal insufficiency due to Al. Works at acidic pH (don't give with PPI, H2RA)
Alosetron: what is it? what do you use it for? why was it withdrawn?
5-HT3 antagonist. Used to tx women with SEVERE IBS-D.
Ischemic colitis, constipation, death
Drugs that cause constipation
verapamil, sucralfate, Ca or Al based antacids
Linaclotide: who not to give it to
Children under 6.
How to treat opioid constipation
peripheral mu antagonists: methylnaltrexone, alvimopan