GI pharm Flashcards Preview

GI-Kevin > GI pharm > Flashcards

Flashcards in GI pharm Deck (12):
1

Antacids: which are absorbable and adverse affects? non absorbable? characteristics?

Mg (diarrhea), Al (constipation), Ca (constipation) based.
NaHCO3 (alkalosis) based.
Rapid onset and short duration

2

H-2RAs: suffix? mechanism? when should they be taken?

-tidine. competitive inhibition. Taken before bedtime (NO EATING afterwards b/c food signal can overcome blockade)

3

H2RA drug interactions

cimetidine inhibits CYP450 (relevant for phenytoin, warfarin, theophylline b/c of narrow therapeutic window)

4

PPIs: suffix? mechanism? side effects?

-prazole. Taken up by parietal cell, protonated, excreted, covalent bond with H/K ATPase (body must make new pump to regain secretion).
Slight risk of C. diff

5

PPI: drug interactions

Omeprazole weakly interacts with phenytoin, warfarin, diazepam, CLOPIDOGREL

6

What do you use PPIs for?

GERD, as part of H. pylori triple therapy (PPI, clarithromycin, amoxicillin), peptic ulcers (idiopathic, NSAID related), bleeding ulcer

7

sucralfate: complications

problematic in pts with renal insufficiency due to Al. Works at acidic pH (don't give with PPI, H2RA)

8

Alosetron: what is it? what do you use it for? why was it withdrawn?

5-HT3 antagonist. Used to tx women with SEVERE IBS-D.
Ischemic colitis, constipation, death

9

Drugs that cause constipation

verapamil, sucralfate, Ca or Al based antacids

10

Linaclotide: who not to give it to

Children under 6.

11

How to treat opioid constipation

peripheral mu antagonists: methylnaltrexone, alvimopan

12

Sulfasalazine: mechanism of activation and action. Used to treat?

split by colonic bacteria into sulfapyridine (toxic) and 5-ASA which has local anti-inflamm effects for ulcerative colitis