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Flashcards in VIral hepatitis Deck (19):
1

markers of hepatocyte inflammation? of biliary tree inflammation?

ALT and AST elevation. Alk Phos and GGT elevation

2

Which (A-E) viruses are chronic? what type of genetic material? Pattern of transmission?

BCD can be chronic (esp C). All except B (dsDNA) are ssRNA. BCD are blood/sexual/parenteral which AE are fecal oral

3

E's of HEV

enteric, expectant mothers, epidemic (waterborne)

4

what type of virus are Hep A-E

Picorna, hepadna, flavi, delta, hepe

5

incubation period for Hep A-E

A-short, B-long, C-long, D-short superinfect and long co-infect, E-short

6

ground glass appearing hepatocytes

Hep B surface Ag in cytoplasm

7

cut off for acute/chronic HBV infection

6 months

8

Significance of Anti-HAV IgM and IgG serum markers

IgM- best test for active hepA. IgG- prior HAV infection and/or vaccination

9

Significance of HBsAg, Anti-HBs

indicates HepB infection.
Indicates immunity to hepB (recovered (will have Anti-HBc) or immunized)

10

Anti-HBc: IgM and IgG.

IgM- acute/recent infection.
IgG- prior exposure or chronic infection. Positive during window period

11

Window period

month in between when HBsAg become indetectable and Anti-HBs become detecatable. Anti-HBc positive during this time.

12

HBeAg and Anti-HBe

second antigenic determinant in HBV core. Indicates active viral replication (high transmissibility)
Indicates low transmissibility

13

ALT>AST, AST>ALT

viral hepatitis, alcoholic hepatitis

14

Markers of HBV infection in the order they appear

SECES: SE antigens, CES antibodies

15

which hepatitis virus is most commonly sexually transmitted? how would it present? which is most commonly associated with blood transfusion

HBV, jaundice
HCV

16

which most commonly lead to HCC

B and C

17

Hep B vaccine is made of___

HBsAg

18

features of acute viral hepatitis histology

lobule necrosis and regeneration, bridging necrosis, massive necrosis

19

features of HCV chronic hepatitis

mononuclear reaction, lymphoid aggregates, steatosis, cirrhosis, HCC