Penicillins

Question 1

Penicillin classification

Answer 1

Based on spectra of activity

Question 2

Penicillin Administration

Answer 2

Most administered parentally

Question 3

Penicillin Distribution

Answer 3

Widely distributed and penetrate into the CSF

Question 4

Penicillin Excretion

Answer 4

Most are excreted by the kidneys. Removed by dialysis except nafcillin and oxacillin

Question 5

Penicillins Half-Life

Answer 5

Half-life is typically 30 to 90 minutes.

Question 6

Penicillins Activity

Answer 6

Time-dependent bactericidal activity and post-antibiotic effect (PAE) against most gram-positive organisms. (PCN G and PCN V)

Question 7

Penicillins Clinical uses

Answer 7

U/LRTI, UTI, CNS and STDs

Question 8

PCNs Mechanism of action

Answer 8

inhibition of bacterial cell growth by interference with cell wall synthesis.

Question 9

PCNs Spectrum of activity

Answer 9

binding to and activating the penicillin-binding proteins (PBPs)

Question 10

PCNs Adverse events

Answer 10

low incidence; most common are hypersensitivity reactions.