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Flashcards in Perinatal Infections Deck (90)
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1

What are the ToRCHES infections?

Toxoplasmosis
Other
Rubella
CMV
HSV/Hep/HIV
Syphilis

2

What are the common ssx of torches infx?

-SGA or IUGR
-Thrombocytopenia
-Jaundice/HSM
-Microcephaly

3

Where is Toxoplasma acquired from?

-Cat feces
-Undercooked meat
-Uncooked eggs
-Unpasteurized milk

4

What should women never do when pregnant?

Change the cat litter box

5

Is there a prenatal screen for toxoplasmosis?

No

6

Is there a risk of transmission of toxo for a secondary or primary infection?

Primarily only

7

When in pregnancy is the will toxo have the most severe effects?

1st trimester

8

What happens to the chances of transmitting toxo with increasing gestational age? What about severity?

Risk of transmission increases

Severity decreases

9

Vertical transmission of toxoplasmosis infection is most likely to occur in what trimester?

2nd and 3rd

10

True or false: the majority of newborns with congenital toxo lack clinical signs

True

11

What is the classic triad of congenital toxoplasmosis? (3)

-Hydrocephalus
-Chorioretinitis
-Intracranial calcifications

12

What are the later signs of toxoplasmosis?

Seizures
Hearing loss

13

What is chorioretinitis? S/sx?

Inflammation of the posterior portion of the uveal tract and retina

Manifests as blurry vision, retinal detachment, or glaucoma

14

What are the characteristics of calcifications (CMV and toxo)?

V if periventricular, but this is CMV

X (diffuse) in toxo

15

How do you diagnose toxoplasmosis? (4)

-Serum IgM or persistent IgG
-Fundoscopic exam
-Head CT
-LP

16

What is the treatment for toxoplasmosis? (4)

-Pyrimethamine
-Sulfadiazine
-Leucovorin
-Corticosteroids

17

True or false: you should treat babies for ANY known or suspected toxoplasmosis infection, even if asymptomatic

True

18

Can you treat mothers in pregnancy for toxo?

Yes

19

What is the incidence of MR and seizures with toxoplasmosis? Deafness?

MR = 87%
Seizures = 82%
Deafness = 15%

20

What percent of adults are susceptible to Rubella?

10%

21

What is the viral family of Rubella?

Togaviridae
+ssRNA

22

What are the ssx of Rubella infections in adults?

Mild cold

23

What is the colloquial name for rubella?

German measles

24

How does rubella spread?

Respiratory droplets

25

What is the most common vaccine-preventable disease in the world?

Rubella

26

Is prenatal screening for Rubella recommended?

Yes

27

What happens to the severity of congenital rubella infection as gestational age increases?

Decreases

28

Maternal infection with Rubella from how many months before may cause neonatal infection?

1 month before conception

29

What are the four major organ systems affected with congenital rubella syndrome?

Eyes
Heart
Brain
Ears

30

What is the most common sequelae of congenital Rubella?

Hearing loss