Pharm Flashcards
(1 cards)
1
Q
Cyclophosphamide
A
MOA= Alkylating agent. Cross links DNA at guanine N-7. Requires bioactivation by liver.
CC=
Vasculitides= Polyarteritis nodosa [medium], Granulomatosis with polyangiitis (Wegener) [small], Microscopic polyangiitis [small]
Solid tumors, leukemia, lymphomas.
Tox= Hemorrhagic cystitis, SIADH Antidote= Mesna coadmin to prevent bleeding
“Stan Tran cycling with cross-link on his chest. Mesna and genius”
