Pharm, Drugs for Obesity Martin Flashcards Preview

Year 2 Psych exam2 > Pharm, Drugs for Obesity Martin > Flashcards

Flashcards in Pharm, Drugs for Obesity Martin Deck (21):
1

phentermine and topiramate ER

most efficacious
>5% weight loss after 56 weeks at highest dose
avg patient went from 260 - 232 lbs

2

side effects phentermine topiramate (qsymia)

discontinuation ~40%
CI in pregnancy
only available through restricted access program designed to prevent fetal exposure

3

orlistat

OTC or Rx
pancreatic and gastric lipase inhibitor that dec absorption of fat

4

adverse effects orlistat

flatulence with discharge
oily spotting
fecal urgency after high fat indescretions
discontinuation
CI during pregnancy

5

Lorcaserin

selective serotonin 2C agonist suppresses appetite
shcedule IV controlled substance

6

patients who should stop taking lorcaserin

fail to lose >5% baseline weight by 12 weeks

7

adverse effects lorcaserin

HA nausea dizziness
CI pregnancy
do not take with MAOI SSRI SNRI

8

bupropion/naltrexone

appetite suppressant/opoid R antagonist

9

adverse effects bupropion/naltrexone

nausea (main reason discontinue)
vomiting, HA, constipation, dizziness and dry mouth
neuropsychiatric reactions

10

liraglutide

injectable GLP-1 agonist used in DM II

11

adverse effects liraglutide

nausea, vomiting, constipation and diarrhea
slows gastric emptying and may dec rate and extent absorption of other drugs

12

box warning on liraglutide

thyroid C cell tumors
CI in pregnancy

13

weight loss in DM on glucose lowering drugs

increase insulin sensitivity and may increase risk of hypoglycemia

14

which off label drug helps with modest weight loss

metformin

15

adjustable gastric banding

restrictive procedure not assoc with malabsorption
loss of excess weight over 10 years

16

sleeve gastrectomy

laparoscopic partial gastrectomy
loss of excess weight over 5 years

17

roux- en Y gastric bypass

mixed restrictive and malabsorptive procedure that involves creation of proximal pouch of stomach and anastomoses to limb of jejunum, bypassing most stomach and duodenum
excess weight loss after 2 years

18

safer gastric surgery

banding

19

Tx for severe binge eating disorder

Vyvanse- used for ADHD

20

most common adult eating disorder in US

severe binge eating disorder

21

adverse effects Vyvanse (lisdexamefatamine)

dry mouth, insomnia, dec appetite, constipation, feeling jittery and anxiety