Pharm, Drugs of Abuse, part II Flashcards Preview

Year 2 Psych exam2 > Pharm, Drugs of Abuse, part II > Flashcards

Flashcards in Pharm, Drugs of Abuse, part II Deck (35):
1

MOA nicotine

selective agonist of nAChR

2

neuronal nAChR are expressed on what neurons

DA neurons in VTA

3

withdrawal of nicotine

mild compared with opioid withdrawal and involves irritability and sleeplessness

4

Tx nicotine

nicotine gum, lozenge, inhalers, transdermal applicaitons

5

bupropion

antidepressant
used alone or combo with nicotine replacement therapy and or behavioral therapy

6

varenicline

derivative of plant extract cytisine
partial neuronal nAChR agonist
only approved for Tx smoking cessation
prevents nicotine stimulation of mesolimbic dopamine system assoc with nicotine addiciton

7

inhalants produce

euphoria

8

overdose management of inhalants

supportive care

9

Cocaine effects in PNS

inhibits vNaCh
can be used local anesthetic

10

CNS effects cocaine

blocks DAT and increases DA concentrations in nucleus accumbens

11

cocaine effects on SANS

blocks NET and activates SANS leading to increase arterial P, tachycardia, ventricular arrhythmia and pupil dilation

12

typical acute Sx of cocaine

loss appetite
hyperactivity
lack of sleep

13

overdose Sx cocaine

hyperthermia
coma
death

14

exposure to cocaine increases risk for

intracranial hemorrhage
ischemic stroke
MI
seizures

15

intoxicaiton management cocaine

supportive and heart rate controllers and seizure controllers
no antidote

16

MOA amphetamines

cause release endogenous biogenic amines by reversing action of biogenic amine transporters at plasma membrane

17

;how are amphetamines taken up to cell

DAT

18

amphetamines block what

intracell cMAT and deplete synaptic vesicles of their NT content causes levels of NT to increase in cytoplasm

19

increasing levels of amines in cytoplasm cause

DAT SERT NET to work in reverse and release maines into synapse

20

withdrawal amphetamines

dysphoria, drowsiness, general irritability

21

MOA ecstasy

reverse action of biogenic amine transporters

22

preferential binding ecstasy

SERT and increase extracellular concentration of serotonin

23

heavy users of ecstasy complain of

long term cognitive impairment due to continued serotonin depletion

24

acute toxic effects of esctasy

hyperthermia, dehydration, serotonin syndrome (mental status change, autonomic hyperactivity, neuromuscular abnormalities) and seizures

25

withdrawal Sx esctasy

mood offset
characterized by depression lasting up to several weeks
possible increased aggression

26

Schedule I drug

high potential abuse
no accepted medical use in Tx
all research use illegal

27

examples schedule I drug

heroin, LSD, weed and methaqualone

28

schedule II drug

high potential abuse
use in medicine with severe restrictions
no refills
cna lead to dependence

29

examples schedule II drug

morphine
PCP
cocaine
methadone
methamphetamine

30

Schedule III drug

less potential for abuse
accepted medical abuse
6 mo or 5 refills

31

examples Schedule III drug

anabolic steroids, codeine, hydrocodone with aspirin or acetaminophen and some barbituates

32

Schedule IV drug

low potential abuse
used medically
prescription rewritten after 6 mo or 5 refills

33

examples of schedule IV drug

propoxyphene, pentazocine, meprobate, dizepam and alprazolam

34

schedule V drug

low potential for abuse
medical use
no prescription needed unless additional state regulations

35

examples of schedule V

cough meds with codeine