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Flashcards in Pharm Final Deck (147)
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1

Thiazide depletes

potassium (fatigue)

2

What antihyperlipidemia drug is water soluble and inhibits lipolysis in adipose tissue

niacin (decr liver triglycerides and lower VLDL and LDL)

3

Skin flush
Pruritis
Nausea
Ab pain

side effects of Niacin

4

stimualtes lipoprotein lipase to breakdown triglycerides into FFA's and remove from plasma

clofibrate (don't use with anticoagulant)

5

Condition where clofibrate is used

hypertryglyceridemia

6

Myositis
Gi disturbance
gall stones

side effects of clofibrate

7

Binds to bile acid and bile salt in SI and excreted in feces

Cholestyramine

8

MC HMG-CoA reductase inhibitors

lovastatin/mevacor
Misvastatin/zocor

9

myopathy
rhabdomyolysis
abnormal liver function

side effects of lovastatin and zocor

10

pregnant and nursing mothers should not take which antihyperlipidemias

lovastatin and zocor

11

prostaglandin synthesis:

phospholipid to arachidonic acid (via cyclooxyrgenase) to prostaglandin

12

prostaglandins stimulate TXA2 for

platelet aggregation

13

aspirin acts as anti-inflammatory by

decr prostaglandin synthesis by inhibiting cyclooxygenase

14

high dose of aspirin can lead to

hyperventilation and respiratory alkalosis

15

do all NSAIDs cause interstitial nephritis?

No. not aspirin

16

Hepatitis w/ cerebreal edema is caused by chicken pox and aspirin: name syndrome

reyes syndrome

17

when is aspirin prescribed

1 antipyretic
2.analgesic/antiinflammatory
3. unstable angina
4. coronary artery thrombosis

18

if patient bleeds in GIT due to aspirin use, they should be given

misoprostol/cytotec

19

aspirin side effects

nausea
vomiting
gastritis
prolonged bleeding
allergy
metabolic acidosis
reyes syndrome

20

lethal dose of aspirin

>13 grams

21

NSAID's that work as anti-inflammatory, analgesic, antipyretic and better than aspirin--work as potent cyclooxyrgenase inhibitors

1. ibuprofen/motrin (fever)
2. naproxen/anaprox

22

Ibuprofen side effects

GI bleed
prolonged bleeding
*interstitial nephritis

23

Indomethacin is prescribed for

RA, AS, Gout

24

indomethacin side effects

GI bleed
*frontal HA
neutopenia
thrombocytopenia

25

most powerful antiinflammaotry

Phenylbutazone (weak antipyretic/analgesic)

26

Aplastic anemia and agranulocytosis are side effects of

phenylbutazone (RA and Gout)

27

acetominophen acts to

inhibit prostaglandin synthesis in CNS (weak antiinflammatory, better antipyretic and analgesic)

28

Tylenol vs aspirin

aspirin prolongs bleeding time, tylenol doesnt

29

how does acetaminophen cause liver damage

can be hydroxylated and become toxic

30

side effects of acetominophen

liver damage (>13g), rash