Pharm Final Flashcards Preview

BOARDS Part 1 > Pharm Final > Flashcards

Flashcards in Pharm Final Deck (147):
1

Thiazide depletes

potassium (fatigue)

2

What antihyperlipidemia drug is water soluble and inhibits lipolysis in adipose tissue

niacin (decr liver triglycerides and lower VLDL and LDL)

3

Skin flush
Pruritis
Nausea
Ab pain

side effects of Niacin

4

stimualtes lipoprotein lipase to breakdown triglycerides into FFA's and remove from plasma

clofibrate (don't use with anticoagulant)

5

Condition where clofibrate is used

hypertryglyceridemia

6

Myositis
Gi disturbance
gall stones

side effects of clofibrate

7

Binds to bile acid and bile salt in SI and excreted in feces

Cholestyramine

8

MC HMG-CoA reductase inhibitors

lovastatin/mevacor
Misvastatin/zocor

9

myopathy
rhabdomyolysis
abnormal liver function

side effects of lovastatin and zocor

10

pregnant and nursing mothers should not take which antihyperlipidemias

lovastatin and zocor

11

prostaglandin synthesis:

phospholipid to arachidonic acid (via cyclooxyrgenase) to prostaglandin

12

prostaglandins stimulate TXA2 for

platelet aggregation

13

aspirin acts as anti-inflammatory by

decr prostaglandin synthesis by inhibiting cyclooxygenase

14

high dose of aspirin can lead to

hyperventilation and respiratory alkalosis

15

do all NSAIDs cause interstitial nephritis?

No. not aspirin

16

Hepatitis w/ cerebreal edema is caused by chicken pox and aspirin: name syndrome

reyes syndrome

17

when is aspirin prescribed

1 antipyretic
2.analgesic/antiinflammatory
3. unstable angina
4. coronary artery thrombosis

18

if patient bleeds in GIT due to aspirin use, they should be given

misoprostol/cytotec

19

aspirin side effects

nausea
vomiting
gastritis
prolonged bleeding
allergy
metabolic acidosis
reyes syndrome

20

lethal dose of aspirin

>13 grams

21

NSAID's that work as anti-inflammatory, analgesic, antipyretic and better than aspirin--work as potent cyclooxyrgenase inhibitors

1. ibuprofen/motrin (fever)
2. naproxen/anaprox

22

Ibuprofen side effects

GI bleed
prolonged bleeding
*interstitial nephritis

23

Indomethacin is prescribed for

RA, AS, Gout

24

indomethacin side effects

GI bleed
*frontal HA
neutopenia
thrombocytopenia

25

most powerful antiinflammaotry

Phenylbutazone (weak antipyretic/analgesic)

26

Aplastic anemia and agranulocytosis are side effects of

phenylbutazone (RA and Gout)

27

acetominophen acts to

inhibit prostaglandin synthesis in CNS (weak antiinflammatory, better antipyretic and analgesic)

28

Tylenol vs aspirin

aspirin prolongs bleeding time, tylenol doesnt

29

how does acetaminophen cause liver damage

can be hydroxylated and become toxic

30

side effects of acetominophen

liver damage (>13g), rash

31

acetominophen overdose, use

N-acetylcysteine

32

lethal dose of aspirin for children

around 7 grams

33

gold salts are used for

RA and other arthritis

34

dermatitis could be caused by **** (WRONG: GOLD SALT)

acetominophen use

35

Severe RA med that is used when no other med works

methyltrexate

36

colchicine is used for

Gout (inhibits lipooxygenase)

37

chronic gout med

allopurinol

38

colchicine fatal dose

8mg in 24hrs

39

action of colchicine

binds to tubular causing depolymerization

40

side effects of colchicine

ab pain
nausea
vomiting
diarrhea**

41

action of allpurinol

decr uric acid by inhibiting xanthine oxidase

42

allergy/skin rashes are side effects seen with

allopurinol

43

median lethal dose ( LD50)

smallest dose given to kill 50% of test group

44

MEdian lethal concentration (LC50)

smallest concentration given to kill 50% of test group

45

threshold limit value

max amount considered safe

46

Simple asphyxants
irritants
systemic toxicants

types of gaseous poisons

47

most rapid acting poisons forming complex with ferric ions of cytochrome oxidase system

cyanide

48

breath of person poisoned with cyanide

bitter almond

49

cyanide antidote

amyinitrite**

50

cherry red cyanosis

carbon monoxide poisoning

51

CO is 200x more affinic than O2

true

52

tx for CO poisoning

100% O2

53

only heavy metal toxin which affects kidney

arsenic

54

arsenic poisoning affects on body

pale bands appear in toenails and fingers

55

arsenic poisoning antidote

dimercaprol

56

MCC heavy metal poisoning

lead via GI and inhalation

57

lead poisoning antidote

dimercaprol, edentate

58

black line on gums, lead encephalopathy are signs of

lead poisoning

59

Mercury poisoning cuases

cardiovascular collapse or anuria

60

nickel itch dermatitis

nickel poisoning

61

metal fume fever

zinc poisoning

62

lethal blood lever of ETOH

0.5g/dl

63

best home drink for poison

milk

64

best emetic at home

syrup of ipecac (aspiration pneumonia)

65

atropine OD

physostigmine

66

Organosulfate/insecticide poisoning OD

atropine

67

tubocurarine OD

neostigmine

68

Physostigmine or neostigmine OD

pralidoxime

69

Hallucinogen OD

haloperidol

70

GI bleeding caused by NSAID's tx

misoprostol

71

acetominophen OD

N-acetylcysteine

72

Cyanide poisoning

amyinitrite

73

arsenic poisoning

dimercaprol

74

lead poisoning

dimercoprol or edetate

75

motion sickness

scopalomine or dramamine

76

used during surgery to relax pt

tubocurarine

77

EC shock tx

succinylcholine

78

shock

dopamine

79

frostbite

phentolamine

80

benign prostatic hypertrophy

terazosin

81

elderly and black hypertension

labetolol

82

used after car accident

valium

83

alcohol withdrawal

disulfiram

84

bed wetting

imipramine

85

partial seizures

carbamazepine

86

petit mal.absent seizure

euthoximide

87

moutnain sickness

acetazolamide/diamox

88

acute pulmonary edema due to CHF

furosemide/lasix

89

edema with nephritic syndrome

hydrochlorothiazide

90

edema due to hepatic cirrhosis

spironolactone/aldactone

91

100% bioavailability

IV

92

phase 1 rxns catalyzed by

cytochrome p450

93

drug metabolism rxn in liver

phase II

94

Phase II metabolism in liver enhanced by

glucouronyl transferase

95

agonist

BINDS to receptor and gets response

96

antagonist

decr action of agonist

97

what synthesizes ACh

choline acetyl transferase

98

beak down ACh

ACH esterase

99

atropine overdose

physostigmine

100

used in myasthenia graves and antidote for tubocurarine

neostigmine

101

antidote for tubcurarine OD

neostigmine

102

drug used in eye exams and tx of diarrhea

atropine

103

organophosphate poisoning tx

atropine

104

used during surgery to relax muscle

tubocurarine

105

pilocarpine does what for glaucoma pts

decr intraocular pressure

106

open angle glaucoma can happen after given

atropine due to mydriatic effect

107

used during electroconvulsive shock

succinylcholine

108

succinylcholine side effects

malignant hyperthermia

109

tx for malignant hyperthermia

dantrolene

110

B2 agonist action

bronchodilation
BV dilation
Incr glucagon releas
relax uterine smooth

111

B1 agonist action

incr HR
incr contraction
Incr lipolysis

112

A2 agonist action

smooth musclerelax
inhibit lipolysis
inhibit NE and renin

113

A1 agonist action

smooth mus contra
close urethra
vasoconstrict
mydriasis

114

drug that incr CO without incr BP

dobutamine

115

bronchial asthma, anaphylactic shock and local anesthetic

epinephrine

116

CHF tx

dobutamine

117

a blocker

(osin)

118

b blocker

(olol)

119

a blocker used to treat frostbite

phentolamine

120

MC b blocker used for young adults and low BP

propanolol

121

valium is good for

agitated person

122

major side effect of phenobarbitol

induce cytochrome p450 to decr action of other drugs

123

drug given for alcohol withdrawal

disulfiram (blocks aldehyde dehydrogenase)

124

theophylline and methylxanthine found in

tea

125

theophylline used for

asthma

126

cocaine works by

blocking reuptake of NE

127

Tricyclic Anti depressants are used in

severe depression and panic attacks(bed wetting)

128

imipramine used for

bed wetting

129

MAO's can cause

hypertensive crisis

130

schizophrenia tx via serotonin blockers

risperidone and clozapine

131

shizo tx via dopamine blockers

haloperidol

132

MU receptors are

strongest

133

codeine is used for

pts with dry cough

134

opioids are contraindicated for

head injuries

135

morphine receptor

Kappa

136

used for partial seizures

phenytoin/dilantin

137

gingival hperplasia

phenytoin/dilantin

138

simple partial seizure med

phenobarbitol

139

absent/petit mal med

ehtosuximide

140

carbamazapine is used for

children with partial seizure

141

diamox acts by

carbonic anhydrase inhibitor

142

mountain sickness tx

acetazolamide

143

loop diuretics incr

Ca

144

acute pulmonary edema by CHF tx

furosemide/lasix

145

synthetic aldosterone antagonist

spironolactone

146

diuretic linked to causing gout

hydrochlorothiazide

147

side effect of thiazide

decr potassium