Pharm - Osteoporosis Flashcards
(11 cards)
1
Q
bisphosphonates MOA
A
1st line
pyrophosphate analogs, bind hydroxyapatite –> taken up by osteoclasts –> osteoclast apoptosis
2
Q
bisphosphonates AE
A
atypical femur fractures (below lesser trochanter)
osteonecrosis of jaw
GI upset
flu-like sx
3
Q
Teriparatide MOA
A
recombinant PTH
- inc bone mass
- inc osteoblast bone form
- inc alpha-1hydroxylase ativity (inc calcitriol)
- inc Ca respor/phos excretion
4
Q
Teriparatide AE
A
theoretical osteosarcoma
5
Q
raloxifene MOA
A
SERM
- estrogen agonist bone (inhib osteoclast diff)
- estrogen antagonist breast/uterus (reduced risk of breast cancer)
6
Q
calcitonin MOA
A
- binds and inhibits osteoclasts
- inhibits bone resorption
- inc Ca excretion
7
Q
Denosumab
A
monoclonal RANK-L Ab
blocks osteoblast activity of osteoclasts
does not get incorporated into bone
8
Q
romosozumab
A
MAb to sclerostin (protein secreted by osteocytes that inhib formation of bone)
9
Q
antiresorptives
A
bisphosphates
SERM (Raloxifene)
Denosumab
Estrogen therapy
10
Q
anabolics
A
teriparatide
abaloparatide
Ramosozumab
11
Q
abaloparatide
A
rPTHrP
