Pharmacology Flashcards Preview

Ophthalmology SOH > Pharmacology > Flashcards

Flashcards in Pharmacology Deck (16):
1

Examples of topical eye drugs

Drops
Ointments

2

What do topical drugs require?

Corneal penetration

3

Lipid soluble drugs penetrate the EPITHELIUM/STROMA and are HYDROPHILIY/LIPOPHILIC

Epithelium
Lipophilic

4

Water soluble drugs penetrate the EPITHELIUM/STROMA and are HYDROPHILIC/LIPOPHILIC

Stroma
Hydrophilic

5

What makes a steroid more hydrophobic?

Alcohol, acetate

6

What makes a steroid more hydrophilic

Phosphate

7

Systemic absorption of topical drugs

Excess topical drug gets deposited at the nasopharynx area due to the tears and it is then absorbed systemically from here

8

Ocular injections - advantages

Delivers effective conc of drug at target site instantly
Prevents the blood retinal barrier from rejecting the drug

9

Ocular injections - disadvantages

Many drugs are toxic to the retina

10

Side effects of steroids

Can cause cataract development
Glaucoma development

11

Name 2 mydratics

Tropicamide
Cyclopentolate

12

Mydratics - function

Causes artificial pupillary dilation by blocking parasympathetic supply to iris

13

Sympathomimetics - function

Acts on the sympathetic system and causes the pupil to dilate

14

3 classes of antibitotics

Inhibit cell wall synthesis
Inhibit protein synthesis
Inhibit nuclei acid synthesis

15

Eye drop bottles - preservative

This keeps the bottle free from contaminants for 4 weeks

16

Contaminated eye drop bottles

If eye bottles are kept after the 4 week period, the preservatives no longer work and pseudomonas can grow