Pharmacology-- Anti-Neoplastics Flashcards Preview

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Flashcards in Pharmacology-- Anti-Neoplastics Deck (20):
1

Cyclosporine

Protects against rejections from organ transplants by dec. t-cell activity through Il-2 inhibition
Does not induce bone marrow suppression

2

Cyclophosphamide

Alkalating agent of both purine & pyrimadine bases of DNA
Tx: CLL

3

Cisplatin's Toxicities

Nephro- and ototoxic

4

Methotrexate

Antimetabolite of folic acid: inhibits dihydrofolate reductase

5

Leucovorin Rescue

Can block/reduce methotrexate.--readily converted to other reduced folic acid derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is equivalent to that of folic acid.
--does not require the action of dihydrofolate reductase for its conversion, so MTX has no effect on it

6

Bleomycin toxicities

Pneomonitis
Pulmonary fibrosis

7

Azathioprine

Use in organ transplant= kidney allografts. Purine analogue, immunosupressant
Inhibits DNA synth enzyme so blocks proliferating cells--> t and b cells dec.
Allopurinol can inc. its activity by inhibiting its biotransformation to xanthine oxidase

8

MOPP

Chemo regimen in Hodgkins
M=Mechlorethamine (nitrogen mustard)
O=oncovin (vincristine)- prevents microtubule assembly
P= procarbazine
P=Prednisone (gluccocorticoid, inducing apoptosis)

9

Tamoxifen

Blocks estrogen receptor
Tx of breast CA, can see an associated endometrial CA

10

Flutamide

Antiadrenergic
Use w leuprolide (LH-RH analog)
Tx: prostate CA

11

Megestrol

Blocks progesterone receptor
Tx: endometrial Ca

12

Fluoxmesterone

adrenergic steroid
Tx: mammary Ca in postmenopausal women

13

Methotrexate

Folic acid analog that blocks tetrahydrofolate synthesis by blocking dihydrofolate reductase
Tx: ALL, psoriasis

14

Brain tumor Tx

Lomustine
Carmustine-- causes pulmonary fibrosis

15

Streptozocin

Attaches to islet beta cells
tx: pancreatic insulinomas

16

Cytrarabine (AraC)

Pyrimidine analog
DOC for AML

17

Dactinomycin

Tx: Wilm's tumor & rhabdomyosarcoma
Blocks transcription initiation complex and preventing elongation of RNA chain by RNA polymerase.--> no transcription

18

Etoposide

Used for oat cell CA (SC lung Ca)
Topoisomerase inhibitor

19

Paclitaxel

Used for ovarian CA
Stabilizes microtubules via tubulin..> no metaphase

20

Amifostine

Can decrease nephrotox of chronic cisplatin use
Detoxifies reactive metabolites of platinum and alkylating agents, scavenges free radicals