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Flashcards in Pharmacology-- CNS Deck (62):
1

TOMS

Short-acting BDZs:
Triazolam
Onazelam
Midazolam

2

Butyrophenone

Derivatives include: Haloperidol & droperidol

3

Atypical D4

Clozapine-Thiroidazine-Olanzepine-Risperidone= Do not cause EPS

4

Flumazenil

BDZ antidote for OD

5

Methylphenidate

Tx for ADHD (trade name Ritalin)
mech: NE/DA reuptake inhibitor

6

Phenytoin

Antiepileptic, stabilizes the inactive state of voltage-gated Na-channels.
Causes aplastic anemia, gingival hyperplasia, cleft lip & palate
Zero order clearance

7

Thiopental

Short acting barbiturate

8

Carbamazepine

DOC for trigeminal neuralgia
Tx lennox gastaut syndrome in kids
tradename: tegretol (also used for BP)

9

Atypical DA antagonists

Thioridazine, Olanzapine, Clozapine

10

Pimozide

antipsychtoic, DA-antagonist
Tx Tourette's, scz

11

Risperidone

Atypical antipsychotic, good for negative sx

12

Thioridazine

Most anticholinergic of the neuroleptics
atypical antipsychotic

13

Haloperidol

Typical antipsychotic
Neuroleptic malignant hyperthermia due to chronic DA-2R block. Give dantrolene and bromocriptine to tx

14

Imipramine

TCA
Tx: Enuresis

15

Clomipramine

TCA
Tx: OCD
See aggressive behavior w/ use

16

Trazodone

SARI -- 5HT antagonist & reuptake inhibitor
May cause PRIAPISM

17

Buproprion

NE-DA reuptake inhibitor
Depression and smoking cessation**

18

SSRIS

MDE & OCD

19

Fluoxetine

SSRI
"good for negative sx"...the fuck does that mean?

20

Phenelzine

Irreversible MAO-I

21

Lithium

Tx: manic phase of BP
SEs:Causes goiter by inhibiting conversion of T4 to T3;Causes nephrogenic DI (thus can be used to tx SIADH);Low salf diet will lead to Li tox

22

Alprazolam

Short acting benzo
Tx: anxiety d/os (social phobia, PD, GAD, etc)

23

Propranolol

Nonselective beta-blocker
tx: performance anxiety

24

opioid kappa-receptor (κ-r)

Spinal analgesia. Euphoria. ++euphoria. ++sedation. Constipation.
Per wikipedia: analgesia, sedation, miosis, inhib. of ADH release, dysphoria

25

opioid mu-receptor (μ-r)

supraspinal analgesia?
μ1: analgesia,physical dependence
μ2: respiratory depression,miosis, euphoria, red.GI motilityphysical dependence
μ3: possible vasodilation

26

Morphine & O2

Admin. is contraindicated for pt.s on morphine.
Sedation: Dec. CO2 sensitivity, and O2 admin can lead to dec. resp drive--> stop breathing

27

Morphine

Opioid analgesic, acts predom. at mu-receptor
Inc ICP= do NOT give to pt w head trauma!

28

Morphine OD

Signs: pin-point pupils, Dec. respiration, coma
Tx: Naloxone

29

Meperidine

Mu receptor agonist, some kappa activity
Anesthetic used during labor
aka Demerol

30

Hydromorphone

mu-r agonist (morphine deriv)
used in renal failure...why? it's cleared renally

31

Tramadol

Ambulatory tx for mod-severe pain
Mech:weak μ-r agonist, induces 5HT release, and inhibits the reuptake of NE

32

Naloxone

Tx for Opiod OD, opiate R antagonist
Reverses respiratory dep
Used in suboxone--> no oral availability

33

Pentazocine

"mixed agonist-antagonist narc"-->Part κ(+) & part μ(-)
Tx: pain

34

Butorphanol

Part κ(+) & part μ(-)
Intranasal for migraine, oral for pain

35

Nalbuphene

Part κ(+) & part μ(-)

36

Inc GABA

Decrease seizure focus = barbs and benzos

37

Decreased Fast Na Channel Activity

Dec electrical activity spread= phenytoin & carbamazepine

38

Methoxyflurane

Volatile inhaled anesthetic
Can be nephrotoxic. Needs low MAC (min. alveolar concen.) for anesthetic induction

39

Enflurane

Volatile inhaled anesthetic
Can be nephrotoxic
Can cause tonic/clonic muscle spasms

40

Isoflurane

Volatile inhaled anesthetic
can cause bronchospasm

41

Halothane

Volatile inhaled anesthetic
Can cause ventricular extrasystoles & Malignant hyperthermia & Hepatitis

42

Nitrous Oxide

Volatile inhaled anesthetic (N2O...NOT NO!!)
No effect on HR. Needs High MAC for anesthetic induction

43

Thiopental

Short acting barb

44

Ketamine

Dissociative anesthetic

45

Droperidol

Can be used in combo w fentanyl for neuroleptoanalgesic effect
Used transdermally for chronic pain
Anti-DA drug

46

Fentanyl

Can be used in combo w Droperidol for neuroleptoanalgesic effect. Neuroleptic tranq, has mild alpha block

47

Midazolam

pre-anesthetic. Induces amnesia

48

Primidone

Biotransformed to phenobarb

49

C& A delta fibers

first fibers to be blocked w anesthesia

50

Esters

Local anesthetics
Procaine, Tetracain, benzocaine. Break down and yield PABA (allergen)
"caines" are locals

51

Amides

Local anesthetics
Lidocaine, Mepivaciane, Bupivaciane, Etidocaine= “i” before “caine” always an amide
metabolized in the liver

52

Amphetamine

DA reuptake inhibitor. MAOI,
Parkinson's Tx

53

Bromocriptine

D2 agonist. Used w L-Dope for "on-off" phenomenon in Parkinson's

54

Benzotropine

Anti muscarinic w some Da reuptake inhibition. Tx: Parkinson's

55

Amantadine

Dec Da reuptake centrally. Tx: Parkinson's
Can cause livido reticularis = skin mottling

56

Diphenhydramine (DPH)

First gen anti-histamine,
Tx: early parkinson's for antichoinergic effects
Rxed for sleep disturbance

57

Pergolide

More effective and longer acting than bromocriptine for Pd. DA and 5HT agonist
WITHDRAWN FROM US MARKET IN 2007
(no ergoline derivs on market)

58

Ethosuximide

DOC for absence seizures
Mech poorly understood

59

Tranylcypromine

MAOI

60

SSRI & MAOI

fatal combo, especially w Paroxetine or fluoxetine plus tranylcypromine

61

Labor opioids

Meperidine and nalbuphine

62

Desipramine

TCA
Causes sudden cardiac death in children!