Pharmacology -- Autonomic Nervous System Flashcards Preview

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Flashcards in Pharmacology -- Autonomic Nervous System Deck (45):
1

Epinephrine

α1, α2, β1, β2

2

Norepinephrine

α1, α2, β1 (no β2 activity)

3

GABA

Causes an inhibitory hyperpolarization of cells

4

Muscarinic receptor

Uses DAG & IP# as second messengers
Parasympathetic control

5

Bethanechol

Cholinergic
Increases GI & Bladder motility
Tx for atonic bladder post-op

6

Pilocarpine

Cholinergic
Pupillary constriction=miosis
Ciliary constriction=accomodation
Tx: acute angle glaucoma

7

Isoflurophate

Organophosphate. Irreversible anti- acetylcholinesterase
Tx glaucoma

8

Pralidoxime

aka 2 PAM
Reverses organophosphate binding to acetylcholinesterase (thus used in organo. phos poisoning. doesn't cross BBB so coadmin w atropine)

9

Neostigmine

Reversible anti-cholinesterase inhibitor
Parasympathomimetic
Tx: Myasthenia gravis

10

Myasthenia Gravis

Antibodies to the ACh Receptor.
Inc. muscular weakness due to Ach's week postsynaptic effect @ NMJ. Inactivates receptors

11

Tubocurarine

Nondepolarizing competitive cholinergic nicotinic ACh receptor antagonist. Prevents Ach binding but does not activate NMJ.
Increases histamine release = dec BP and inc bronchospasm
Tx: skeletal muscle relaxant used w anasthesia (less commonly used currently due to side effects)

12

Trimethaphan

Nonselectively, competitively binds the nicotinic receptor of both PS and SNS
short acting, IV admin.

13

Pancuronium

More potent than tubocurium, competitive nicotinic Ach-R antagonist at NMJ, w/o the histamine release

14

Succinylcholine

Depolarizing noncompetitive cholinergic nicotinic receptor antagonist of muscle action
Opens Na Channels= fasiculations, closes Na channels= paralysis= persistent depol at NMJ
Continuous infusion

15

alpha1 and eye

Mydriasis (pupil dilation) due to NE.
Prozsin blocks (alpha-adrenergic blocker, specific for the alpha-1 receptors.)

16

Muscarinic receptor and the Eye

Miosis due to Ach.
Atropine blocks

17

Sympathetic Neurons

post ganglionic sympathetic fibers release NE

18

Parasympathetic Neurons

Post-ganglionic parasympathetic fibers release Ach

19

M3 receptor and the Eye

Contracts sphincter = miosis
Contracts ciliary bodies= accomodation

20

M2 receptor and the heart

Negative chronotropy. Dec HR= vagal arrest
Negative inotropy. Dec contractility

21

M3 receptor and the lung

Bronchospasm, inc. secretions

22

M3 receptor and the GI tract

Inc motility (cramps and diarrhea). Involuntary defecation

23

Tacrine

Centrally acting anticholinesterase and indirect cholinergic agonist (parasympathomimetic).
Tx: Alzheimers

24

Atropine

competitive Muscarin Ach R antagonist
"DOC w/ vagal arrest"

25

Glycoperrolate

Muscarinic receptor antagonist. Antispamodic
Tx: peptic ulcers

26

Pirenzepine

Muscarinic receptor antagonist. Antispasmodic.
Tx: peptic ulcers

27

Doxacurium

Most potent competitive non-depol NMJ receptor antagonist. No CV side effects. No histamine release

28

Beta-bungarotoxin

Prevent the release of Ach from vesicles at the presynaptic nerve terminal

29

alpha-bungarotoxin

Irreversible nicotinic receptor antagonist. Decreased action potentials

30

alpha1 & eye

contracts radial muscle= mydriasis (dilation)

31

alpha1 and arterioles

Constriction. Inc TPR= Inc diastolic pressure=Inc afterload

32

Alpha1 and venules

Constriction= Inc venous return= inc preload

33

alpha1 and sexual fct.

Ejaculation

34

Increased Diastolic Pressure

Inc alpha1= Inc TPR

35

Decreased diastolic pressure

Increased Beta2; direct acting vasodilators; cholinergics

36

Beta1 and heart

positive chronotropism = Inc HR
Positive inotropism= Inc contractility, Inc SV, Inc CO, Inc O2 consumption, Inc conduction velocity

37

Phenylephrine

Alpha 1 agonist.
Nasal decongestant

38

Beta2 agonist Asthma drugs

Metaproterenol; Albuterol; terbutaline; ritodrine; salmeterol

39

Ritodrine/turbutaline

Relaxes myometrium -- used in premature labor pains

40

Phentolamine

Epinephrine reversal. Blocks alpha receptors, vasodilation occurs. Pt goes from hypertensive to hypotensive
Tx: pheochromocytoma to dec BP

41

Terazosin

Txt BPH (alpha 1 antagonist)

42

Yohimbine

Inc sympathetic outflow= alpha2 antagonist
Tx: impotence

43

Cardioselective NMJ

Pancuronium= Inc HR due to atropine-like antimuscarinic vagolytic effect and gallamine receptor antagonist--- whaaat

44

Ecothiophate

Irreversible acetylcholinesterase inhibitor
-parasympathomimetic

45

Pyridostigmine

Cholinomimetic that increases muscarinic and nicotinic receptor effects. Acetylcholinesterase inhibitor and plasma cholinesterase inhibitor
DOC (drug f choice?) for the oral tx of MG