Flashcards in Pharmacology -- Autonomic Nervous System Deck (45):
α1, α2, β1, β2
α1, α2, β1 (no β2 activity)
Causes an inhibitory hyperpolarization of cells
Uses DAG & IP# as second messengers
Increases GI & Bladder motility
Tx for atonic bladder post-op
Tx: acute angle glaucoma
Organophosphate. Irreversible anti- acetylcholinesterase
aka 2 PAM
Reverses organophosphate binding to acetylcholinesterase (thus used in organo. phos poisoning. doesn't cross BBB so coadmin w atropine)
Reversible anti-cholinesterase inhibitor
Tx: Myasthenia gravis
Antibodies to the ACh Receptor.
Inc. muscular weakness due to Ach's week postsynaptic effect @ NMJ. Inactivates receptors
Nondepolarizing competitive cholinergic nicotinic ACh receptor antagonist. Prevents Ach binding but does not activate NMJ.
Increases histamine release = dec BP and inc bronchospasm
Tx: skeletal muscle relaxant used w anasthesia (less commonly used currently due to side effects)
Nonselectively, competitively binds the nicotinic receptor of both PS and SNS
short acting, IV admin.
More potent than tubocurium, competitive nicotinic Ach-R antagonist at NMJ, w/o the histamine release
Depolarizing noncompetitive cholinergic nicotinic receptor antagonist of muscle action
Opens Na Channels= fasiculations, closes Na channels= paralysis= persistent depol at NMJ
alpha1 and eye
Mydriasis (pupil dilation) due to NE.
Prozsin blocks (alpha-adrenergic blocker, specific for the alpha-1 receptors.)
Muscarinic receptor and the Eye
Miosis due to Ach.
post ganglionic sympathetic fibers release NE
Post-ganglionic parasympathetic fibers release Ach
M3 receptor and the Eye
Contracts sphincter = miosis
Contracts ciliary bodies= accomodation
M2 receptor and the heart
Negative chronotropy. Dec HR= vagal arrest
Negative inotropy. Dec contractility
M3 receptor and the lung
Bronchospasm, inc. secretions
M3 receptor and the GI tract
Inc motility (cramps and diarrhea). Involuntary defecation
Centrally acting anticholinesterase and indirect cholinergic agonist (parasympathomimetic).
competitive Muscarin Ach R antagonist
"DOC w/ vagal arrest"
Muscarinic receptor antagonist. Antispamodic
Tx: peptic ulcers
Muscarinic receptor antagonist. Antispasmodic.
Tx: peptic ulcers
Most potent competitive non-depol NMJ receptor antagonist. No CV side effects. No histamine release
Prevent the release of Ach from vesicles at the presynaptic nerve terminal
Irreversible nicotinic receptor antagonist. Decreased action potentials
alpha1 & eye
contracts radial muscle= mydriasis (dilation)
alpha1 and arterioles
Constriction. Inc TPR= Inc diastolic pressure=Inc afterload
Alpha1 and venules
Constriction= Inc venous return= inc preload
alpha1 and sexual fct.
Increased Diastolic Pressure
Inc alpha1= Inc TPR
Decreased diastolic pressure
Increased Beta2; direct acting vasodilators; cholinergics
Beta1 and heart
positive chronotropism = Inc HR
Positive inotropism= Inc contractility, Inc SV, Inc CO, Inc O2 consumption, Inc conduction velocity
Alpha 1 agonist.
Beta2 agonist Asthma drugs
Metaproterenol; Albuterol; terbutaline; ritodrine; salmeterol
Relaxes myometrium -- used in premature labor pains
Epinephrine reversal. Blocks alpha receptors, vasodilation occurs. Pt goes from hypertensive to hypotensive
Tx: pheochromocytoma to dec BP
Txt BPH (alpha 1 antagonist)
Inc sympathetic outflow= alpha2 antagonist
Pancuronium= Inc HR due to atropine-like antimuscarinic vagolytic effect and gallamine receptor antagonist--- whaaat
Irreversible acetylcholinesterase inhibitor