Pharmacology Capstone Flashcards Preview

Neuro I > Pharmacology Capstone > Flashcards

Flashcards in Pharmacology Capstone Deck (90)
Loading flashcards...
0

sympathetic nervous system is aka

thoracolumbar

1

parasympathetic nervous system is aka

craniosacral

2

Parasympathetic NT and R

NT=Ach
R=NAchR, MAchR

3

Sympathetic NT and R

NT= NE>epi>Da; Ach
R= alpha, Beta, D, nAchR, mAchR

4

Cholinergic - think?

acetyl choline
muscarinic and nicotinic receptors

5

adrenergic think?

norepinephrine
epinephrine
dopamine

alpha, beta, D receptors
from tyrosine

6

major NT of the parasymp system

Ach

7

found at ALL PREganglionic autonomic fibers

Ach

8

found at ALL POST ganglionic parasympathetic fibers

Ach

9

found at a few POSTgaglionic sympathetic fibers (WHERE?)

Ach
sweat glands

10

major NT of the sympathetic nervous system

NE

11

found at a vast majority of postganglionic sympathetic fibers

NE

12

synthesis occurs in adrenal medulla and a few neuronal pathways in brainstem

EPI

13

Synthesized in the cytoplasm of neurons

Dopamine

14

Dopamine has actions where?

in the CNS and renal vascular smooth muscle

15

Neurons that release Ach are called

cholinergic neurons

16

Order of steps in cholinergic neurotransmission

Synthesis
storage
release
binding
termination

17

Synthesis of Ach

CHOLINE TRANSPORTER transports choline into neurons
dependant on cotransport with NA

CHOLINE ACETYLTRANSFERASE (ChAT) conbines acetyl coenxyme A with choline to make Ach

18

Storage of Ach

ATPase dependent Ach vesicular transporter transports Ach into neuronal vesicles.

19

Release of Ach

AP reaches axon terminal, causes opening of VgCa2+channels
Ca2+enters the neuron
Ca2+ influx promotes fusion of vesicular membrane with cell membrane
Ach is released

the SNARE protein complex is responsible for fusion of the vesicle membrane and synaptic membrane through VAMP and SNAP proteins

20

Binding of Ach to cholinergic receptors

Ach diffuses across the synaptic cleft
binds nachrs which facilitates Na entry into post-gang fiber or release of epi/NE from adrenal medulla
post-synaptic machrs are also activated by ach causing smooth muscle contraction, decrease in HR, glandular secretin etc

Ach can bind to and activate both nachr (+) and machr (-) to modify its own release.

21

activation of prejunctional nAchRs _________ Ach release

stimulates/potentiates

22

activation of prejunctional machrs ________further release

inhibits

23

Termination of Ach signaling

Acetylcholinesterase cleaves Ach into acetate and choline
acetate diffuses out of the synapse
choline is recycled into the nerve

24

What two types of receptors does Ach bind to?

nAchR
mAchR

25

Where are NnAchrs found

all ganglia (sym and parasymp) and adrenal medulla (symp)

26

where are mAChrs found

smooth and cardiac muscle
gland cells
nerve terminals

27

nAchR is what type of a channel

ionotropic (ligand gated ion channel)

28

nAchR allows what to pass through the channel

Na

29

mAchR is what type of receptor

metabotrpoic, GPCR