PHYS 3 renal transport mechanisms Flashcards Preview

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Flashcards in PHYS 3 renal transport mechanisms Deck (33)
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1

Transepithelial transport

must go across what 5 barriers?

2

why filter a lot of blood then reabsorb 99% of it?

why not filter and excrete the 1% that needs to be eliminated?

3

Draw the overview of reabsorption of the nephron

4

essentials of the proximal tubule

reabsorbs what?

keh element in proximal tubule reabsorption is?

 

5

changes in concentration in proximal tubule

special feature?

glucose and AA?

Na?

H2O?

what increases?

6

Na-K-ATPase in PCT

what is the mechanism of action?

7

ways to transport?

ATPases location?

8

route specifications

in order to reach the blood reabsorbed substances must either?

9

Transcellular vs paracellular route

 

10

what does most of the energy used for reabsorption go towards? 

what route will Na usually go down?

 

11

Transporting Na?

can be broken down to 3 steps?

12

what is used to get Na into the tubule cells?

this is important for what other absorption?

what two questions does this bring up?

13

How is bicarbonate reabsorbed?

start with?

transporters?

H?

Carbonic anhydrase is key

14

Chloride reabsoption

what drives this?

15

water movement and paracellular movement

when would there be movement vs when would there not?

16

Water and transcellular route

what help?

 

17

net water permeability of renal tubule is determined by?

proximal tubule?

ascending limb?

Collecting duct?

18

19

Glucose

reasorbed how?

specific mechanism

20

diabetes and glucose transport

21

transport maximum

what is it?

in reference to glucose?

actual numbers?

22

Descending loop of Henle

permeable to what? what percent?

how does it move?

impermeable?

causes?

 

23

ascending reabsorbs what?

doesnt reabsorb?

thick ascending does what?

has what?

what does furosemide do?

24

what transporter transports what on the apical membrane (thick limb)?

how about the basolateral?

what about charge?

what other things will be reabsorbed?

what can cause problems in reabsorbing these?

25

difference in filtering in a normal/high potassium diet and a low potassium diet/potassium depletion

 

26

countercurrent multiplier

loop of Henle

27

DIstal tubule

normally reabsorbs what? how much?

major mechanism apical and basolateral?

how much of the originally filtered Na and H2O remain here?

impermeable to?

What pharmaceutical action can be done?

28

Collecting ducts

reabsorption at this point?

ADH?

Aldosterone?

how much Na usually leaves in urine?

what can be a big problem?

29

Aldosterone

what causes release?

what mechanism would either cause aldosterone to be released?

30