PHYS 2.5 Intro to Renal blood flow and glomerular filtration rate Flashcards Preview

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Flashcards in PHYS 2.5 Intro to Renal blood flow and glomerular filtration rate Deck (32)
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1

Glomerular filtration barrier

three layers?

2

glycocalyx does what

governs and acts as what?

proteins that bind to glycocalyx?

a barrier?

response to inflammation? 

  • The endothelial glycocalyx governs transcapillary fluid exchange and acts as a biomechanical sensor
  • proteins that bind to the glycocalyx include proteins involved in cell attachment, migration, differentiation, morphogenesis, blood coagulation, lipid metabolism, and inflammation

  • can be a size barrier to albumin filtration

  • (fiber mesh with pores)

  • glycocalyx-degrading enzymes such as hyaluronidase, heparanase endosulfatases, and proteinases. (in response to disease process)

3

What passes the filtration barrier?

Freely filtered?

Not freely filtered?

FIltered components depend on size and charge

 

4

Tamm-Horsfall protein

Cells in the thick ascending limb produce Tamm-Horsfall glycoprotein and secrete it into the tubular fluid.  protein reabsorption is "upstream" of thick ascending limb Tamm-Horsfall appears in urine

 

Need more than trace proteins to be indicative of disease

5

what can happen with a damaged filtration barrier?

 

Both can be due to a damaged filtration barrier

Hematuria

  • alport syndrome (collagen in basement membrane mutation)

Proteinuria

  • increase in urinary protein 
  • increase permeability of glomerular capillaries
  • loss of normal podocyte structure ( thinning of foot process)

 

6

Cortex vs medulla for difference of the microcirculation

Cortex has a much higher blood flow than the medulla

the outer medulla has a little more than the inner medulla

7

Kidneys receive how much blood?

microcirculation consists of what capillary networks?

 

8

the peritubular capillaries can be further broken down into?

9

Renal blood flow

renal fraction

glomerular caps pressure? favors?

peritubular caps pressure? favors?

during exercise?

10

filtered load?

FIltered load of X = (Plasma concentration of X) (GFR)

filtered load= amount of substance X that is filtered into the bowmans space in a given amount of time

Actual filtereed depends on amount that is bound (wont get filtered) and amount free (will get filtered)

 

11

Urinary excreation=

Tubular reabsorption=

what if excretion > filtration?

12

Urine excretion rate of x?

13

Renal clearance

rate at which?

formula?

for a v= 1.44 L/day is the same as 1 mL/min

14

15

Glomerular filtrate

16

GFR

formula for FF?

how to calculate GFR from RBF and vise versa

 

glomerular filtration rate

RBF- renal blood flow?

RPF- renal plasma flow

FF-filtration fraction

RBF approx RPF

17

FF what is it?

how does the amount effect blood pressure and oncotic pressure?

with more RBF out filtered means a more concentrated arteriole so more oncotic pressure

18

changes to FF?

19

filtered load vs filtration factor

20

basic processes of urine formation

what processes will lead to urine formation

(where are things filtered etc)

21

Ex of net reabsorption of Na

filtered load

reabsorption equals?

excretion

how these 3 interplay together.

variables at play?

percentage of Na reabsorbed?

22

renal clearance link to GFR?

this is true when?

23

inulin tells us what?

why?

24

creatinine clearance 

 

25

clinical situations GFR usually determined by?

however pros and cons to this?

26

SNS on arterial vessels, juxtaglomerular cells, and epithelial cells?

all to do what?

27

Receptor subtypes for

arterial resistance vessels

JG cells

Na-K ATPase

28

Effects of sympathetic stimulation

Immediately?

eventually?

29

plasma creatinine concentration and GFR related how?

increase GFR what happens to plasma creatinine levels?

30

BUN:Creatinine ratio

tells us?

what ratio for what problem?

isolate the etiology of a pathology to a pre, intra, or post-renal source