PHYS 2 Renal Blood flow and glomerular filtration rate Flashcards Preview

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Flashcards in PHYS 2 Renal Blood flow and glomerular filtration rate Deck (20)
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1

forces causing filtration by the glomerular capillaries?

favoring filtration

opposing filtration

2

formulas and how to determine net fluid filtration, no net movement, and net fluid reabsorption

3

Three physical factors contribute to GFR

GFR=

4

Ultrafiltration pressure (formula)

what can alter PUF?

what determines PGC 

 

5

ultrafiltration coefficient 

whats the formula?

what influences Kf?

what change SA/permeability?

glomerular mesangial cells?

6

hydrostatic pressures in renal vasculature

where do we see sharp declines

where is there an interesting plateau?

7

Ultrafiltration pressure along the glomerular capillary from afferent to efferent arteriole.

 

we lose fluid and cant lose larger proteins and such so the oncotic pressur in glomerular capillaries increases while the hydrostatic pressure decreases due to resistance of flow

8

different combinations of constricting and dilating afferent and efferent arterioles will have what effect on GFR and RBF?

9

Renal blood flow

kidney vs brain oxygen consumption

in kidney O2 consumption related to?

10

physiological control of glomerular filtration and RBF

11

intrinsic vs extrinsic control mechanism for renal hemodynamics

12

sympathetic exert what on renal blood vessels?

what receptors?

vasoconstrictors?

vasodilators? 

13

Glomerulotubular balance 

14

Autoregulation

maintains what?

what two things will help with this?

autoregulatory range

80-170 mmHg

15

Local myogenic feedback reflex

16

Tubuloglomerular feedback

what senses what?

what is maintained?

 

17

Tubuloglomerular feedback

in case of increased renal perfusion presssure/

When the GFR increases and causes the NaCl concentration of tubular fluid at the macula densa to rise, more NaCl enters macula densa cells. This process leads to an increase in the formation and release of adenosine triphosphate (ATP) and adenosine, a metabolite of ATP, by macula densa cells, which causes vasoconstriction of the afferent arteriole. Vasoconstriction of the afferent arteriole returns the GFR to normal levels

18

tubuloglomerular feedback

in the case of decreased renal perfusion pressure

afferent?

efferent?

mediated by?

when the GFR and NaCl concentration of tubule fluid decrease, less NaCl enters macula densa cells, and the production and release of ATP and adenosine decline. The decrease in ATP and adenosine causes vasodilation of the afferent arteriole, which returns the GFR to normal

19

increase sensitivity of TGF?

decrease?

20