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Flashcards in physio postmidterm Deck (12):
0

Familial renal glycosuria

SGLT mutation. Glucose not entering cells in early proximal tubule, not being reabsorbed in urine. Blood glucose would be normal -> no tx needed

2

Cystinuria

Dibasic amino acid carrier defects in early proximal tubule

3

Hartnup's disease

Neutral amino acid carrier defects in early proximal tubule (Trp)

4

NHE3

Early proximal tubule. Na+ and H+ exchanger. Main method of Na+ reabsorption. Upregulated by angiotensin II and NE

5

NKCC2

Thick ascending loop of Henle, transports Na+, 2Cl-, K+. Upregulated by ADH (ROMK is also affected)

6

Bumetanide and furosemide

Loop diuretics that block NKCC2 in thick ascending loop of Henle

7

Bartter's syndrome

Mutations in any of NKCC2, ROMK, or CLC-kb

8

Gittelman's syndrome

NCCT mutation in early distal tubule

9

Thiazide diuretics

Block NCCT in early distal tubule

10

Liddle's syndrome

ENaC gain of fxn

11

Pseudohypoaldosteronism (PHA)

ENaC loss of fxn

12

ENaC

Collecting duct. Upregulated by aldosterone (ROMK also upregulated). Blocked by amiloride-like diuretic