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DCNP Review > Precancerous And Cancerous Lesions > Flashcards

Precancerous And Cancerous Lesions Flashcards

1
Q

Green tea polyphenol is the active ingredient in

A

Ingenue Mebutate

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2
Q

The topical treatment for AKs that acts by activating toll like receptor 7 is:

A

Imiquimod

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3
Q

A hyperkeratotic AK on the scalp has been treated with cryosurgery on 2 previous occasions within the past 3 months. Your next action should be

A

Biopsy

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4
Q

The type of BCC that appears like a depressed area of induration and may be mistaken for a scar describes:

A

Morpheaform

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5
Q

The type of BCC that upon histology palisading and clefting is a prominent feature

A

Nodular

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6
Q

The most common type of BCC

A

Nodular

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7
Q

A patient presents with a BCC located on the lower back. The lesion is pink, appearing pedunculated smooth papule. What type of BCC does this represent?

A

Fibroepithelioma

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8
Q

Imiquimod has FDA indication for what type of BCC?

A

Superficial

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9
Q

A 56-year-old male presents with an 8 mm nodular BCC located on the nose. The best treatment for this is

A

Mohs surgery

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10
Q

What are potential side effects of vismodegib?

A

Nausea, weight loss, alopecia

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11
Q

A 68-year-old male patient with advanced BCC has been prescribed Vismodegib. He is currently taking warfarin, lisinopril, metformin, furosemide and rantidine. Which medication would be contraindicated for Vismodegib use?

A

Rantidine

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12
Q

Most patients with low grade asymptomatic cutaneous B-cell lymphoma should be treated by

A

Watchful waiting

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13
Q

There is a possible link to the development of cutaneous B-cell lymphomas with which infection agent?

A

Borrelia

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14
Q

Almost all patients with cutaneous B-cell lymphomas will react positive to which marker?

A

CD20

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15
Q

What is an important diagnostic histological clue for primary cutaneous margin zone B-cell lymphoma?

A

Dutcher bodies

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16
Q

What is a diagnostic finding for the diagnosis of sezary syndrome?

A

Peripheral blood smear demonstrating sezary cells

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17
Q

UV photo carcinogenic starts with what process?

A

DNA damage

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18
Q

Prolonged chemical exposure to what substance is linked to the development of non-melanoma skin cancer?

A

Asphalt

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19
Q

True or false: UV exposure early in life has a large influence on development of subsequent skin cancers

A

True

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20
Q

Solid organ transplant patients have an increased risk of developing skin cancers. Which one has the highest risk of developing?

A

SqCC

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21
Q

What are characteristics of keratoacanthomas?

A

Occur mostly in patients with Fitzpatrick skin type 1 and 2, incidence data may not be accurate due to similarities with SqCC and tendency to regress.

22
Q

The 3rd stage of the more common forms of keratoacanthomas can be described as:

A

Regression which occurs over several months that causes atrophy and scarring

23
Q

True or False: Intralesional Methotrexate or 5FU have been shown to be the treatment of choice for the more common singular KA

A

False

24
Q

True or False: The damage for UVA rays is indirect, while the damage from UVB rays is direct.

A

True

25
Q

The most common subtype of melanoma is

A

Superficial spreading

26
Q

Mrs. Jones presents for routine dermatologic exam. On her arm is a 1 cm brown-black 2 toned papule. With questioning, she endorses 2 occasions of spontaneous bleeding from the lesion. You determine a biopsy is warranted. What is the best choice of biopsy technique?

A

Excisional

27
Q

Intrinsic risk factors for melanoma include:

A

atypical appearing nevi, # of regular appearing nevi and hx of melanoma in the past 10 years

28
Q

Alex is a 32-year-old female recently diagnosed with a 4.7 mm ulceratwd superficial spreading melanoma of the left calf. The T stage of her melanoma is?

A

T4b

29
Q

What type of mutation is seen in approximately 50% of cutaneous melanomas?

A

BRAF

30
Q

True or False: Checkpoint inhibitors work through the immune system and have direct tumor effect.

A

True

31
Q

For a melanoma-in-situ on the cheek of an 88-year-old male, the appropriate surgical margin would be?

A

0.5 cm peripheral margins

32
Q

True or False: Melanomas can occur anywhere on the body, including those with little or no history of UV exposure.

A

True

33
Q

The most common type of mastocytosis in childhood onset is:

A

Mastocytoma

34
Q

The presence of vesicles/bullae may occur in which type mastocytoma?

A

Childhood onset

35
Q

One of the most common sites for the adult onset mastocytosis is

A

Proximal extremities

36
Q

Elicitstion of an urticaria response when a mastocytosis lesion is stroked is described as

A

Darier’s sign

37
Q

A patient with mastocytosis has no clinical signs other than the cutaneous lesions. CbC is normal. What lab test should be obtained and monitored periodically?

A

Tryptase levels

38
Q

Bowen’s disease is a term often interchanged for

A

SqCC-in-situ

39
Q

Erythroplastic of Queyrat type of SqCC is located where

A

Penis

40
Q

Bowenoid papulosa is a type of SQCC-in-situ often associated with which type of HPV?

A

Type 16&18

41
Q

Buscke-Lowenstein tumor is located where?

A

Genitals

42
Q

Risk factors for SQCC metastasis include what?

A

Immunosuppression, SqCC developing in scar tissue, poorly differentiated invasive histology

43
Q

SqCC metastasis is most likely to occur in which organ?

A

Lung

44
Q

A female patient in her 60s arrives at a clinic visit extremely concerned about a lesion. She states the lesion is new, rough feeling and has 2 colors. Your decision to biopsy is based on:

A

Presence of variegated color, new lesion, lack of similar lesions elsewhere and to alleviate the Patient’s concern.

45
Q

The WHO-EORTC classification system labels Mycosis Fungoids as an

A

Aggressive Behavior Type

46
Q

Classic mycosis fungoides accounts for what percentage of all CTCLs?

A

60%

47
Q

Early lesions of mycosis fungoides will most likely occur in what areas?

A

Trunk

48
Q

Early stages of Mycosis Fungoides may resemble

A

Eczema, Medication Reaction

49
Q

A common side effect of topical nitrogen mustard is

A

Skin irritation

50
Q

Bexarotene is classified as a

A

Retinoid

51
Q

10-year survival rate for patients with CTCL that has limited patch/plaque lesions is approximately

A

97%

DCNP Review (12 decks)

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