Systemic Disease And Genodermatoses Flashcards

1
Q

Illicit drug use may lead to delusions of parasites. This condition is more commonly associated with what drug?

A

Amphetamines

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2
Q

Which illicit drug can be associated with development of raynaud’s phenomenon?

A

Cocaine

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3
Q

Tooth decay and eventual loss of teeth are associated with chronic use of

A

Amphetamines

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4
Q

“Skin tracks,” scars and hyperpigmentation from injecting illicit drugs can be located anywhere on the body but first signs are usually found

A

On the arms

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5
Q

Injecting an illicit drug under the skin (skin popping) is used by abusers of

A

Cocaine

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6
Q

Cutaneous symptoms of injecting illicit drugs may include

A

Hyperpigmented sites over veins, granulomas, abscesses

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7
Q

Development of acne type lesions in a male body builder may be linked to

A

Anabolic steroids

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8
Q

Porphyria disorders are caused by deficiency in

A

Heme biosynthesis pathway

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9
Q

The ratio of prevalence between acquired and hereditary etiology of porphyria cutaneous tarda is

A

3 to 1

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10
Q

A common trigger for porphyria cutaneous tarda is

A

Alcohol

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11
Q

The medications most often associated with an acute porphyria attack include

A

Antimalarials

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12
Q

Treatment for non acute porphyria is

A

Phlebotomy of 500 ml of blood every 2 weeks

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13
Q

A deficiency of ferrochlatase is the etiology for

A

Erythropoietic Protoporphyria

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14
Q

Von Recklinghausen disease is another term for

A

Neurofibromatosis type 1

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15
Q

Crowe’s sign is the presence of

A

Intertriginous freckling

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16
Q

Plexiform neurofibromas are most commonly located on

A

Extremities

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17
Q

Lisch nodules are most common in what age group?

A

Adults

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18
Q

Patients with neurofibromatosis should have periodic evaluation by their primary care provider, dermatologist and

A

Ophthalmologist and neurologist

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19
Q

The thick hyperkeratosus of epidermal and non-epidermal palmar plantar hyperkeratosis is colored

A

Yellow

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20
Q

Keratolytics act by

A

Reduction of corneocytes

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21
Q

Star-fish shaped keratosis over the knuckles is a finding in

A

Vohwinkel syndrome

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22
Q

What keratoderma is associated with hyperhidrosis?

A

Pachyonychia congenital

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23
Q

A 5 year old female presents with her mother for treatment of a want. Mother states they’ve been using a home treatment of salicylic acid with no improvement. The lesion is on the right arm, linear, veruccal appearing and 7 cm in length. This lesion is most likely a

A

Inflammatory linear verrucous epidermal nevus(ILVEN) is a type of skin overgrowth, called epidermal nevus. It is characterized by skin colored, brown, or reddish, wart-like papules (nevi). The nevi join to form patches or plaques that often follow a pattern on the skin known as the “lines of Blaschko”

24
Q

Icthyosis is a condition involving disorders of

A

Keratinization

25
Q

Icthyosis vulgaris is due to a mutation in which gene

A

Filaggrin

26
Q

Which other dermatological conditions are often associated eith icythosis?

A

Atopic dermatitis

27
Q

The mechanism of action for humectants is

A

Attraction of water into the epidermis

28
Q

Which type of ichthyosis only occurs in males?

A

Steroid sulfates deficiency

29
Q

Lamella ichythosis often causes eye problems if

A

Ectropian

30
Q

Macrophage is a type of

A

Histiocyte

31
Q

Langerhan cells function as an

A

Antigen presenting cell

32
Q

Langerhan cell histiocytoses occurs predominantly in which age group

A

Young children

33
Q

Bony lesions of langerhan cell histiocytoses occur most commonly in which location?

A

Cranium

34
Q

Kidney shaped nuclei are likely to be demonstrated in the pathology of

A

Langerhan cell histiocytoses

35
Q

The most common type of non-langerhan histiocytoses is

A

Juvenile xanthogranulomas

36
Q

The lesions and pattern of those lesions in Hailey-Hailey disease can be similar to other dermatological conditions including

A

Intertrigo, candidates, darier’s

37
Q

Darier’s disease is an

A

Autosomal dominant inheritance pattern

38
Q

Most cases of Darier’s disease have an onset of what age range

A

6-20 years old

39
Q

Darier’s disease is more common in

A

Females

40
Q

The pathogenesis of Darier disease is due to a mutation in ATP2A2 which causes a defect of what substance in the endoplasmic reticulum?

A

Calcium

41
Q

What is characteristic of the lesions associated with darier disease?

A

Hyperkeratotic reddish brown papules located on the trunk, longitudinal ridging of nails, keratotic papules located on the palmoplantar surfaces

42
Q

The histology findings of a lesion of darier disease will demonstrate

A

Hyperkeratosis and acantholysis

43
Q

A secondary mediator of pruritis is

A

Substance P

44
Q

Which antihistamine blocks H1 and H2?

A

Doxepin

45
Q

Eruptive xanthomas are reflective of increased levels in?

A

Triglycerides

46
Q

Topical treatment options for acanthosis nogricans includes

A

Tretinoin

47
Q

Muehrcke nails can be found in

A

Cirrhosis

48
Q

Wilson’s disease is related to transport problems in?

A

Copper

49
Q

Eruption of multiple seborrheic keratosis within a few months is seen in

A

Leser-Trelat Syndrome

50
Q

Primary cutaneous forms of amylodosis

A

Macular, lichenoid, nodular

51
Q

The “rippled” pattern of skin lesions in amylodosis can be seen in

A

Macular and lichenoid

52
Q

The term macroglossia describes an enlarged

A

Tongue

53
Q

An example of psychophysiological disorders (where emotional distress can exacerbate symptoms)?

A

Psoriasis

54
Q

Examples of primary psychological disorder (where the condition causes cutaneous symptoms)

A

Delusions of parasitoses, OCD, trichotillomania

55
Q

Examples of secondary psychological disorders (where a disfiguring skin condition causes psychological problems like depression)

A

Acne, vitiligo, alopecia