Pregnancy & Cystic Fibrosis Flashcards Preview

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Flashcards in Pregnancy & Cystic Fibrosis Deck (15)
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1

Amniotic fluid (AF)

regulates fetus temp, allows fetus movement, serves as influx & efflux of constituents for fetus

2

Amniocentesis

drawing out the amniotic fluid via ultrasonograph
tests:
congenital diseases
neural tube defects
HDFN
fetal pulmonary disease

3

how far along before amniocentesis?

25-26 weeks
only go before that if fearful of a congenital disease & want to abort

4

Neural Tube defects

test mother for AFP, hCG, unconjugated estriol, & inhibin A
acetyl cholinesterase (AChE)
infant should swallow & metabolize AFP, when they do not see an increased AFP in AF & in mother's serum

5

Acetyal Cholinesterase indicates?

indicates infant has spina bifida or open spine

6

Fetal Lung maturity

need surfactant or else alveoli sacs will collapse & not open again due to increased surface tension

7

fetal lung development by 24th week

type I cells
type II cells
as lung matures see increased PG, lecithin

8

type I cells

form alveolar capillary membrane for gas exchange

9

Type II cells

produce & store surfactant needed for alveolar stability and form lamellar bodies

10

L/S ratio

'gold standard' for fetal lung maturity
lecithin/sphingomyelin ratio based on sphingomyelin raises slow & lecithin increases as lung mature
>2.0

11

PG

phosphatidylglycerol or PG & lecithin compared to sphingomyelin levels
immunoassays

12

Fluorescence Polarization

fluorescent dye combinded w/ albumin & surfactant in the AF
albumin stays constant so increase is due to surfactant

13

Lamellar Body Count

newest & most commonly used
use platelet analyzer
as lungs mature, the lamellar bodies increase
30k-40k = mature lung

14

Cystic Fibrosis

autosomal recessive disorder that affects the exocrine glands & causes electrolyte & mucous secretion abnormalities
primary cause of deaeth is pneumonia, secondary to heavy abnormal viscous mucus in lungs leading to blockages & pancreatic insufficiency

15

testing

chromosome 7 CFTR mutation- does not move chloride ions causing sticky mucus to build up on the outside of the cell
sweat test