Psyco

Question 0

SNRI

Answer 0

Depression, can become mania
generalized anxiety,
panic disorder.
Diabetic peripheral neuropathy

Question 1

SSRI

Answer 1

social phobia.
Depression
OCD
bulimia
PTSD
generalized anxiety, 
panic disorder,

Question 2

TCA

Answer 2

bedweTTing
OCD
mAjor depression, 
fibromyalgia.
Side defect:
Convulsions, coma, cardiotoxicity.

Question 3

MAO

Answer 3

Atypical depression, and society,
Contraindication: use with SSRI, TCA and St. John wort, meperidine,dexthorphan
Side effect:Hypertensive crisis

Question 4

Tolerance of opiates does not develop in?

Answer 4

Miosis and constipation

Question 5

methylphenidate

Answer 5

increase catecholamine at the synaptic cleft,especially ne and DA
used in ADHD, narcolepsy, appetite control
Chronic use will cause desentization, do not stop suddenly->suicidal

Question 6

dextroamphetamine

Answer 6

increase catecholamine at the synaptic cleft,especially ne and DA
used in ADHD, narcolepsy, appetite control
Chronic use will cause desentization, do not stop suddenly->suicidal

Question 7

methamphetamine

Answer 7

increase catecholamine at the synaptic cleft,especially ne and DA
used in ADHD, narcolepsy, appetite control
Chronic use will cause desentization, do not stop suddenly->suicidal

Question 8

Haloperidol

Answer 8

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:+++, sedation,alpha blocker, m block:+, high potency
dystonia–>akathisia–>bradykinesia–>tardive dyskinesia
Neuroleptic malignant syndrome

Question 9

trifluoperazine

azine

Answer 9

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal, sedation,alpha blocker, m block, high potency(EPS)
dystonia–>akathisia–>bradykinesia–>tardive dyskinesia
Neuroleptic malignant syndrome

Question 10

fluphenazine

azine

Answer 10

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:+++, sedation,alpha blocker, m block:+,high potency
dystonia–>akathisia–>bradykinesia–>tardive dyskinesia
Neuroleptic malignant syndrome

Question 11

thioridazine

azine

Answer 11

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:+, sedation,alpha blocker, m block:+++, low potency
dry mouth, constipation,hypotension, sedation,retinal deposition
Neuroleptic malignant syndrome

Question 12

chlorpromazine

azine

Answer 12

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:++, sedation,alpha blocker, m block:+++, low potency
dry mouth, constipation,hypotension, sedation, corneal deposition
Neuroleptic malignant syndrome

Question 13

olanzapine

Answer 13

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+;sedation:-; alpha block: ++, M block:+
significant weight gain!!!

Question 14

clozapine

Answer 14

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+/-;sedation:+; alpha block: +++, M block:++
significant weight gain!!!
agranulosytosis(weekly WBC monitoring) and seizure

Question 15

quetiapine

Answer 15

atypical antipschotic, block 5HT/ACh
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
sedation:++; alpha block: ++,
very expensive!!!!

Question 16

risperiodone

Answer 16

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+;sedation:+/-; alpha block: ++, M block:+/-

Question 17

aripiprazole

Answer 17

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+;sedation:+/-; alpha block: +/-, M block:+/-
partial anta D2, block 5-HT

Question 18

ziprasidone

Answer 18

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS;sedation; alpha block; M block:
prolong QT

Question 19

Lithium

Answer 19

*inhibit phosphoinositol cascade, IP3
*mood stabilizer for bipolar disorder, blocks relapse and acute manic events, also in SIADH
*tremor,sedation, edema, heart block, hypothyrodism(t4x>t3)
polyuria(ADH antagonist)–>nephrogenic DI
terotogenesis, fetal cardiac ebstein anomaly and vessel malformation
excrete by kidney, reabsorbed in proximal following Na
remove by amilorides, thiazide and loop all decreased clearance

Question 20

buspirone

Answer 20

stimulates 5-HT 1A receptors
generalized anxiety disorder, takes 1-2 wks to take effect
do not cause sadation, addiction, tolerance
do not interact with alcohol
“I am anxiety if the bus will come on time”

Question 21

venlafaxin

Answer 21

SNRI,inhibit reuptake of NE &5 HT, mild DA
antidepressant, general anxiety disorder,panic disorder
tox: increase BP, stimulant effects, sedation, nausea

Question 22

duoloxetine

Answer 22

SNRI,inhibit reuptake of NE &5 HT, greater effect on NE
antidepressant, diabetic peripheral neuorpathy
tox: increase BP, stimulant effects, sedation, nausea

Question 23

Atomoxetine

Answer 23

selective NE uptake inhibitor

Question 24

fluoxetine

Answer 24

SSRI, serotinin-specific reuptake inhibitor anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety, bulimia,depression Tox: GI distress, sexual dysfunction, serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

Question 25

paroxetine

Answer 25

SSRI, serotinin-specific reuptake inhibitor anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety, bulimia,depression Tox: GI distress, sexual dysfunction, serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

Question 26

sertraline

Answer 26

SSRI, serotinin-specific reuptake inhibitor anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety, bulimia,depression Tox: GI distress, sexual dysfunction, serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

Question 27

citalopram

Answer 27

SSRI, serotinin-specific reuptake inhibitor anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety, bulimia,depression Tox: GI distress, sexual dysfunction, serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

Question 28

amitriptyline

Answer 28

TCA, blocks reuptake of NE and serotonin major depression, fibromyalgia sedation alpha blocking-hypotension M blocking-tachy, retention, dry mouth, more than alpha blocking Triple c: convulsion, cardiotoxicity(NaHCO), Coma

Question 29

nortriptyline

Answer 29

TCA, blocks reuptake of NE and serotonin use in: major depression, fibromyalgia tox: sedation, alpha blocking-hypotension, less than amitriptyline M blocking-tachy, retention, dry mouth,"confusion and hallucination in elderly" Triple c: convulsion, cardiotoxicity(NaHCO), Coma,

Question 30

imipramine

Answer 30

TCA, blocks reuptake of NE and serotonin major depression, fibromyalgia,BED WETTING sedation alpha blocking-hypotension M blocking-tachy, retention, dry mouth, Triple c: convulsion, cardiotoxicity(NaHCO), Coma

Question 31

DESIPRAMINE

Answer 31

``` TCA, blocks reuptake of NE and serotonin major depression, fibromyalgia sedation alpha blocking-hypotension M blocking-tachy, retention, dry mouth, Triple c: convulsion, cardiotoxicity(NaHCO), Coma ```

Question 32

clomipramine

Answer 32

``` TCA, blocks reuptake of NE and serotonin major depression, fibromyalgia, "OCD" sedation alpha blocking-hypotension M blocking-tachy, retention, dry mouth, Triple c: convulsion, cardiotoxicity(NaHCO), Coma ```

Question 33

doxepin

Answer 33

``` TCA, blocks reuptake of NE and serotonin major depression, fibromyalgia sedation alpha blocking-hypotension M blocking-tachy, retention, dry mouth, Triple c: convulsion, cardiotoxicity(NaHCO), Coma ```

Question 34

amoxapine

Answer 34

``` TCA, blocks reuptake of NE and serotonin major depression, fibromyalgia, "OCD" sedation alpha blocking-hypotension M blocking-tachy, retention, dry mouth, Triple c: convulsion, cardiotoxicity(NaHCO), Coma ```

Question 35

tranylcypromine

Answer 35

nonselective MAO inhibitor increase amine neurotransmitter(NE, DA, 5-HT) atypical depression,anxietym hypochondriasis tox: HTN crisis (ingestion of tyramine), CNS stimulation contraindicated with SSRI, TCA, St John's Wort, meperidine, dextromethorphan

Question 36

Phenelzine

Answer 36

nonselective MAO inhibitor increase amine neurotransmitter(NE, DA, 5-HT) atypical depression,anxietym hypochondriasis tox: HTN crisis (ingestion of tyramine), CNS stimulation contraindicated with SSRI, TCA, St John's Wort, meperidine, dextromethorphan

Question 37

Isocarboxazid

Answer 37

nonselective MAO inhibitor increase amine neurotransmitter(NE, DA, 5-HT) atypical depression,anxietym hypochondriasis tox: HTN crisis (ingestion of tyramine), CNS stimulation contraindicated with SSRI, TCA, St John's Wort, meperidine, dextromethorphan

Question 38

selegiline

Answer 38

MAO-B: increase DA, used in Parkinson's disease

Question 39

bupropion

Answer 39

``` smoking cessation increase NE and DA Tox: stimulant effects: tachy, insomnia headache seizure in bulimic pts no sexual effect ```

Question 40

varennidine

Answer 40

bind to Nic receptor | smoking cessation

Question 41

mirtazapine

Answer 41

alpha2 anta(increase release of NE and serotonin) potent 5 HT2 and 5HT3 receptor antagonist toxicity: sedation: helpful in depress pt with insomnia increase appetite, weight gain: helpful in elderly or anorexis pt dry mouth

Question 42

maprotiline

Answer 42

blocks NE reuptake | toxicity:sedation, orthostatic hypotension

Question 43

trazodone

Answer 43

primary inhibits serotonin reuptake used primarily for insomnia as high doses are needed for antidepressant TOX: sedation, nausea, priapism:thrombosis->ischemia, prolonged erection postural hypotension