resp

Question 0

Dimenhydrinate

Answer 0

1st generation H1 blocker
allergy, motion sickness
toxic: sedation anti-muscar, anti-alpha

Question 1

Diphehydramine

Answer 1

1st generation H1 blocker
allergy, motion sickness
toxic: sedation anti-muscar, anti-alpha

Question 2

Chlorpheniramine

Answer 2

1st generation H1 blocker
allergy, motion sickness
toxic: sedation anti-muscar, anti-alpha

Question 3

Loratadine

Answer 3

2nd generation H1 blocker
allergy
toxic: far less sedating, decrease CNS entry

Question 4

fexofenadine

Answer 4

2nd generation H1 blocker
allergy
toxic: far less sedating, decrease CNS entry

Question 5

desloratadine

Answer 5

2nd generation H1 blocker
allergy
toxic: far less sedating, decrease CNS entry

Question 6

cetirizine

Answer 6

2nd generation H1 blocker
allergy
toxic: far less sedating, decrease CNS entry

Question 7

Albuterol

Answer 7

beta-agonist
relaxes bronchial smooth muscle, beta2
use during acute exacerbation

Question 8

salmeterol

Answer 8

long acting agents for prophylaxis
adverse are tremor and arrhythmia
beta-blocker

Question 9

formoterol

Answer 9

long acting agents for prophylaxis
adverse are tremor and arrhythmia
beta-blocker

Question 10

theophylline

Answer 10

methylxanthine: bronchodilation by inhibiting phosphodisterase
thereby decrease cAMP hydrolysis
usage is limited:narrow therapeutic index (cardiotoxicity, neurotocity)
metabolize by P450: -by:quinolones/macrolides;
+by: aromatic hydrocarbons(smoke),cruciferous vege
block actions of adenosine

Question 11

ipratropium

Answer 11

competitive block of muscarinic receptor
preventing bronchoconstriction
asthma also used for COPD
long acting muscarinic anta

Question 12

tiotropium

Answer 12

competitive block of muscarinic receptor
preventing bronchoconstriction
also used for COPD
long acting muscarinic anta

Question 13

beclomethasone

Answer 13

steroids, inhibits the synthesis of virtually all cytokines
inactive NK-kappaB, the transcription factor that induces the production of TNF-alpha, among other inflammatory factors
1st line therapy for chronic asthma
*oral rinsing! candiasis

Question 14

fluticasone

Answer 14

steroid: inhibits the synthesis of virtually all cytokines
inactive NK-kappaB, the transcription factor that induces the production of TNF-alpha, among other inflammatory factors
1st line therapy for chronic asthma
*oral rinsing! candiasis

Question 15

montelukast

Answer 15

block leukotriene receptor

especially good for aepirin-induced asthma

Question 16

zafirlukast

Answer 16

block leukotriene receptor

especially good for aepirin-induced asthma

Question 17

zileuton

Answer 17

a 5-lipoxygenase pathway inhibitor

blocks conversion of arachidonic acid to leukotrienes

Question 18

omalizumab

Answer 18

monoclonal anti-Ig E antibody
binds mostly unbound serum Ig E
used in allergic asthma resistant to inhaled steroids and long-acting beta2 agonists
*reserve for refractory asthma

Question 19

cromolyn sodium

Answer 19

prevent degranulation of mast cell

Question 20

nedocromil

Answer 20

prevent degranulation of mast cell

Question 21

asthma emergency uses?

Answer 21

epi

Question 22

guaifenesin

Answer 22

expectorant
thins respiratory secretions
does nor suppress cough reflex

Question 23

N-acetylcysteine

Answer 23

mucolytic-can loose mucous plugs in CF patients

also used as an antidote for acetaminophen overdose

Question 24

Bosentan

Answer 24

treat pulmonary arterial hypertension competitively antagonizes endothelin-1 receptors decreasing pulmonary vascular resistance

Question 25

dextromethorphan

Answer 25

antitussive(anta NMDA glutamate receptor) synthesis codeine analog mild opioid effect when used in excess, mild abuse potential naloxone can be given for overdose

Question 26

pseudoephedrine

Answer 26

sympathomimetic alpha-agonistic nonprescription nasal decongestants reduce hyperemia, edema, and nasal congestion, open obstructive Eustachian tubes, pseudoephedrine also used as a stimulant toxicity: hypertension. can also cause CNS stimulation/anxiety

Question 27

phenylephrine

Answer 27

sympathomimetic alpha-agonistic nonprescription nasal decongestants reduce hyperemia, edema, and nasal congestion, open obstructive eustachian tubes, toxicity: hypertension.

Question 28

methacholine

Answer 28

muscarinic receptor agonist | used in asthma challenge test

Question 29

methylene blue

Answer 29

methHb treatment

Question 30

cyanide poisoning

Answer 30

nitrite+thiosulfate

Question 31

DVT treatment

Answer 31

heparin for acute | wafarin for long term prevention

Question 32

neonatal resp distress syndrome

Answer 32

maternal steroid before birth artificial surfactant for infant supplemental O2-->retinopathy of prematurity and bronchopulmonary dysplasia

Question 33

treatment for sleep apnea

Answer 33

weight loss CPAP surgery

Question 34

inoperable lung cancer

Answer 34

small cell carcinoma | treat with chemo

Question 35

lung cancer that need to be removed surgically

Answer 35

large cell carcinoma