Quantitative Genetics Flashcards

1
Q

What are some qualities of qualitative traits?

A

-discrete phenotypic classes
-discontinuous variation in F2

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2
Q

What are some qualities of quantitative traits?

A

-continuous variation
-no distinct F2 classes

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3
Q

What is the multiple-factor hypothesis?

A

phenotypic expression depends on additive effects, as the number of loci affecting the trait increases so does the number of phenotypic classes

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4
Q

Variation can be due to

A

genotype and the environment

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5
Q

Continuous variation is when

A

the characteristics exhibited cover a continuous range of phenotypes

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6
Q

A “normal distribution” is…

A

a bell-shaped curve.

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7
Q

What are the different components of phenotypic variance?

A

Genotypic Variance, Vg
Environmental Variance, Ve
Additive Genetic Variance, Va
Dominance Genetic Variance, Vd

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8
Q

Phenotypic variance equation

A

Phenotypic variance = Genetic variance (genotype) + environmental variance

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9
Q

Genotypic variance equation

A

Genetic variance=Additive genetic variance + dominance genetic variance

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10
Q

To determine phenotype and genotype equation values you must look at the

A

population

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11
Q

The effect of the gene depends on the…

A

environment in which it is found

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12
Q

Interactions that we will ignore are…

A

Vge is a part of the Vp equation
Vi is a part of the Vg equation

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13
Q

Heritability is used to

A

tell the rate of selection response in a breeding program

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14
Q

Broad-sense heritability is the…

A

phenotypic variance due to some genetic effect

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15
Q

Broad-sense heritability equation

A

H^2=Vg/Vp

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16
Q

Narrow-sense heritability is the…

A

phenotypic variance due to additive genetic effects

17
Q

Narrow-sense heritability equation

A

h^2=Va/Vp
h^2=R/S

18
Q

Heritability ranges from 0 to 1. If it equals 0 then ____________, if it equals 1 then __________.

A

all Vp is due to environmental variation, all Vp is due to genetic variation

19
Q

The higher the heritability the…

A

more progress we can expect from a selection/breeding program

20
Q

Environmental variance equation

A

(Vparent1 + Vparent 2 + Vf1)/3

21
Q

Response to selection is

A

the extent to which the characteristic changes over a generation

22
Q

Selection differential (S) equation

A

S = Xs -Xo
S = (average new breed) - (original average)

23
Q

Response to selection (R) equation

A

R = X1 - Xo
R =(average of offspring) - (average original)

24
Q

Realized heritability equation

25
Limits to selection response
-may decline after selecting a particular characteristic in a population for a long period -due to genetic variation being lost -extremes may not be healthy -two desirable traits may be negatively correlated
26
How are quantitative trait loci mapped using GWAS?
They are identified by linkage analysis between the trait and molecular markers. SNPs are used to identify QTL
27
In GWAS anything above the line is
statistically different
28
Limitations to heritability
-doesn't say how much genes affect the trait -individuals don't have heritability
29
Monozygotic vs Dizygotic Twins
-Monozygotic: genetically identical same womb -Dizygotic: only 50% of genetics shared, different wombs
30
Concordant vs Discordant
Concordant: twins same for traits Discordant: twins differ in trait
31
Twin studies can be used to estimate what?
genetic and environmental influences on traits
32
When MZ ratio is high & DZ ratio is low...
Indicates significant role of genetic effects
33
Similar MZ & DZ indicates...
a lot of variation due to environmental factors
34
When MZ ratio is low & DZ ratio is high...
indicates genetic predisposition, but environmental factors are important