label this gland
serous deminlunes are only seen in the ___ gland
where is the nucleus in serous cells?
where is the nucleus in mucus cells?
pushed back towards basolateral side
describe the components needed to produce saliva
know this well
describe the two stage saliva secretion model
what allows saliva to have unidirectional secretion in acinal cells?
what are the important transporters in stage 1 of saliva secretion?
if you block Ik1 OR Maxi-K potassium channels what happens? what about if you block both?
- block one or the other - no change in saliva secretion
- block both - saliva secretion reduced by about 30%
describe stage 2 NaCl reabsorption and potassium secretion in saliva secretion
know the Cftr chloride channel
what are the 4 protein secretion pathways?
- constitutive pathway
- constitutive-like pathway
- major regulated pathway
- minor regulated pathway
describe the constitutive pathway of protein secretion
transport cell membranes protein in vesicles to cell membrane and does not require neurotransmitters
describe the constitutive-like pathway of protein secretion
transport of secretory proteins in vesicles that bud from golig minimal agonist concentration
describe the major regulated pathways of protein secretion
rapid release of granules that fusion to the luminal cell surface, high doses of neurotransmitter
describe the minor regulated pathways of protein secretion
slow release of granules of vesicles that release from maturing secretory granules, low doses of neurotransmitter (human common salivary protein I)
saliva is 99.5% ___
what are the 11 functions of saliva?
- ion reservoir
- antimicrobial actions
- pellicle formation
- water balance
what is sjogren's syndrome?
an autoimmune disease that generally affects women of postmenopausal age
lymphocytes infiltrate salivary glands and affect function
describe side effects of radiation treatment on salivary glands
lots of collagen present, and destruction of the glands
protein secretion occurs as a complete fusion of ___ at the ___ membrane
- secretory granules
in saliva secretion, basolateral transporters concentrate ___ above its electrochemical gradient
salivary gland function is impaired in which 4 major conditions?