QUIZ 3 Salivary Gland Secretion Flashcards Preview

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Flashcards in QUIZ 3 Salivary Gland Secretion Deck (22)
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1

label this gland

2

serous deminlunes are only seen in the ___ gland

submandibular

3

where is the nucleus in serous cells?

centered

4

where is the nucleus in mucus cells?

pushed back towards basolateral side

5

describe the components needed to produce saliva

know this well

6

describe the two stage saliva secretion model

7

what allows saliva to have unidirectional secretion in acinal cells?

tight junctions

8

what are the important transporters in stage 1 of saliva secretion?

9

if you block Ik1 OR Maxi-K potassium channels what happens?  what about if you block both?

  • block one or the other - no change in saliva secretion
  • block both - saliva secretion reduced by about 30%

10

describe stage 2 NaCl reabsorption and potassium secretion in saliva secretion

know the Cftr chloride channel

11

what are the 4 protein secretion pathways?

  • constitutive pathway
  • constitutive-like pathway
  • major regulated pathway
  • minor regulated pathway

12

describe the constitutive pathway of protein secretion

transport cell membranes protein in vesicles to cell membrane and does not require neurotransmitters

13

describe the constitutive-like pathway of protein secretion

transport of secretory proteins in vesicles that bud from golig minimal agonist concentration

14

describe the major regulated pathways of protein secretion

rapid release of granules that fusion to the luminal cell surface, high doses of neurotransmitter

15

describe the minor regulated pathways of protein secretion

slow release of granules of vesicles that release from maturing secretory granules, low doses of neurotransmitter (human common salivary protein I)

16

saliva is 99.5% ___

water

17

what are the 11 functions of saliva?

  • fluid/lubricant
  • ion reservoir
  • buffer
  • cleansing
  • antimicrobial actions
  • agglutination
  • pellicle formation
  • digestion
  • taste
  • excretion
  • water balance

18

what is sjogren's syndrome?

an autoimmune disease that generally affects women of postmenopausal age

lymphocytes infiltrate salivary glands and affect function

 

19

describe side effects of radiation treatment on salivary glands

lots of collagen present, and destruction of the glands

20

protein secretion occurs as a complete fusion of ___ at the ___ membrane

  • secretory granules
  • apical

21

in saliva secretion, basolateral transporters concentrate ___ above its electrochemical gradient

chloride

22

salivary gland function is impaired in which 4 major conditions?

  • sjogren's syndrome
  • post-irradiation
  • developmental defects
  • drug-induced xerostomia