QUIZ 2 Tooth Development Flashcards Preview

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Flashcards in QUIZ 2 Tooth Development Deck (70)
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1

what are two examples of patterning defects of human dentition?

tooth agenesis (absence of teeth) and cleidocranial dysplasia (development of 3rd layer of teeth)

2

what is the paradigm for organogenesis? (tooth morphogenesis)

  • positional information - where they need to be
  • shape determination
  • size variance
  • cell proliferation and migration
  • terminal differentiation
  • specialized matrix foramtion
  • programmed cell death 

3

all organs develop from ___ and ___ layers

epithelium and mesenchymal

4

what guides organogenesis?

epithelial-mesenchymal interactions

5

cell communication is mediated by ___

signaling molecules

6

growth factors turn on transcription factors, which control which 3 things in development?

proliferation, differentiation, and apoptosis

7

what is the difference between autocrine and intracrine signaling?

  • autocrine signaling involves the cell releasing a factor that has an affect on itself
  • intracrine involves the cell producing a factor that affects itself, but never actually leaves the cell first 

8

___ interactions are critical in development

cell-cell

9

___ interactions dictate morphogenesis and differentiation

cell-matrix

10

what does the cranial neural crest give rise to?

  • ganglia and nerves
  • adrenal medulla
  • ectomesenchyme of bones and teeth
    • dentin
    • bone
    • cementum
    • periodontal ligament

11

what is developed by 37 days in utero?

  • stomatodeum or primitive mouth
  • covered by primitive epithelium
  • embryonic connective tissue also referred to as ectomesenchyme

12

describe the dental lamina

  • becomes the future tooth bud
  • outer primary epithelial band
  • ectomesenchyme below (cells are more loosely packed)
  • meckel's cartilage within ectomesenchyme

13

cell proliferation at the dental lamina causes ___

thickening

 

14

label this photo

15

what are the six stages of crown development?

  • initiation - induction
  • bud stage - proliferation
  • cap stage - proliferation, differentiation, morphogenesis
  • bell stage - proliferation, differentiation, morphogenesis
  • apposition stage - induction and proliferation
  • maturation stage - maturation

16

what are the structures formed in the initiation stage?

lamina and bud

17

what are the structures formed in the morphogenesis stage?

cap and early bell

18

what is the structure formed in the cell terminal differentiation stage?

late bell

19

what structures are formed in the matrix synthesis stage?

dentin, enamel, and cementum/bone

20

what stage of development is the tooth type (incisor, premolar, molar, etc.) determined?

morphogenesis stage (cap, early bell)

21

proliferation of epithelium produces buds at how many locations along each dental lamina?

10

22

each bud is the precursor of the ___ for each deciduous tooth

enamel organ

23

at the bud stage, ___ acts along with ___, ___, and ___ to stimulate the mesenchyme to express transcription factors ___, ___, ___, and the ECM molecules ___ and ___, and more ___

  • at the bud stage, BMP-4 acts along with Fgf-8, Lef-1, and shh to stimulate the mesenchyme to express transcription factors, Msx-1, Msx-2, early growth response-1 (Egr-1), and the ECM molecules syndecan and tenascin and more BMP-4.

24

what is induction?

the process where one tissue changes the development of surrounding tissues

25

what does Lef-1 do in the initiation stage of tooth development?

stimulates the pre-dental ectoderm to produce Fgf-8

26

what does Fgf-8 do in the initiation stage of tooth development?

induces the underlying mesenchyme to express Pax-9 and Msx-1 beneath the thickened dental lamina

27

what do BMP-2 and BMP-4 do?

inhibit Fgf-8

28

label this photo

what stage of tooth development is depicted?

early cap stage

a condensation of the ectomesenchyme associated with the epithelial cap is identified easily

29

label this photo

what stage of tooth development is depicted?

cap stage

the epithelial enamel organ sits over a mass of ectomesenchymal cells, the dental papilla that extends around the rim of the enamel organ to form the dental follicle

30

in the cap stage, unequal proliferation of ___ cause a cap to form

bud cells