QUIZ 3 Dentin Pulp Complex II Flashcards Preview

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Flashcards in QUIZ 3 Dentin Pulp Complex II Deck (61)
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1

the pulp is intimately connected to and continuous with the ___

dentin

2

the pulp allows the tooth organ to respond to ___

external stimuli

3

the death of the pulp is a critical event in the long term ___ of the tooth

mechanical stability

4

what is the primary cell type of pulp?

fibroblasts, followed by odontoblasts

5

dental pulp arises from the ___, which is ___ tissue

  • dental papilla
  • ectomesenchymal

6

dental pulp provides the support structures for the mineralized components of the tooth.  what are the individual support structures?

  • blood vessels
  • innervation
  • fibroblasts
  • pool of immune cells
  • pool of progenitor cells for replacement and repair

7

what are the 4 histological zones of the dental pulp, from outer to inner?

  1. odontoblast layer
  2. cell free zone of Weil
  3. cell rich (cell dense zone)
  4. pulp core

8

label this photo

9

the dental pulp ECM is a ___ matrix, comprised of collagen ___ (mostly) and collagen ___.  it also contains numerous noncollagenous ___ and ___.

  • soft connective tissue
  • III
  • I
  • proteoglycans
  • glycoproteins

10

what happens to the dental pulp ECM with age?

collagen content increases and fibrils aggregate into larger bundles, with the greatest concentration apically

11

what composes the ground substance of the pulp?

  • proteoglycans (GAG chains)
  • glycoproteins
  • water (physiological fluid)

12

what are the 5 proteoglycans found in pulp?

  • chondroitin-6-sulfate
  • chondroitin-4-sulfate
  • herparin sulfate
  • dermatan sulfate
  • keratan sulfate

13

label this picture

14

what do proteoglycans in the dental pulp do?

pull in water; keep the squidly bits squidgy

15

what is the key dentin-pulp complex cell type?

odontoblasts

16

describe the odontoblast components and morphology

  • polarized cells, elongated nucleus at the pulpal side of the cell, secretory components (golgi bodies) towards the dentinal side
  • larger and more columnar in the crown than the root, where they are more cuboidal

17

odontoblasts form a discrete layer of cells held together by ___

  • junctional complexes
    • adherens junctions, NOT zonular

18

odontoblasts are held together by junctional complexes, which may give a degree of ___ to the odontoblast layer

permeability (serum proteins may pass)

19

odontoblasts can form ___ with pulpal fibroblasts

gap junctions

20

odontoblasts produce and secrete ___ and ___

collagen and non-collagenous protein

21

odontoblasts are responsible for the production and sequestration of which key growth factors in dentin matrix?

  • VEGF
  • TGF beta 1
  • BMP-2

22

describe aged odontoblasts

fewer organelles, less secretory activity, and nucleus is somewhat more central

23

growth factors can be released via ___ primarily from the odontoblast process

secretory vesicles

24

describe odontoblast turnover

assumed to be long lived, but can be replaced from mesenchymal progenitor pool

the process is not understood, key to responsiveness of tooth and capacity for self-repair

25

there is a role of ___ in dentin matrix in the recruitment of new odontoblasts

sequestered growth factors

26

___ are found in the pulp core and the cell rich zone

fibroblasts

27

fibroblasts produce and maintain the ___ of the pulpal tissue

supportive matrix

28

the pulpal tissue matrix supports what 5 things?

  • progenitor cells
  • immune cells
  • vasculature
  • lymph
  • nervous tissue

29

___ may have a role in facilitating mesenchymal progenitor cell recruitment and differentiation

fibroblasts

30

what are dental pulp progenitor cells?

  • mesenchymal progenitor cells present in dental pulp
  • in response to damage to the dentin, they are recruited to form new odontoblast-like cells
  • involved in reparative dentin formation