QUIZ 3 Salivary Gland Development Flashcards Preview

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Flashcards in QUIZ 3 Salivary Gland Development Deck (26)
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1

are salivary glands ectodermal or endodermal in origin?

  • majority of people believe they are of ectodermal origin
  • experiments in mice that study p63 genes provide evidence that they are of ectodermal origin

2

what are the stages of salivary gland development?

3

salivary gland development occurs mostly at the ___ stage

pre-natal

4

if you combine salivary mesenchyme with mammary epithelium (nasal or pituitary), what happens?

salivary gland pattern with milk secretion

5

if you combine salivary gland E13 (pseudoglandular) with mammary mesenchyme (mandibular arch limb bud), what happens?

failure to branch (aka failure to undergo morphogenesis)

6

at what stages of gland development can you culture salivary gland cells?

  • initial bud (12.5 weeks)
  • pseudoglandular (13.5 weeks - best)
  • you will NOT get growth if you try to culture cells from the prebud stage

7

if you try to culture salivary epithelium alone, will it develop?

no

8

what can you add to salivary epithelium for it to develop in culture?

matrigel or salivary mesenchyme

9

___ has been used as the main model to study salivary gland differentiation

the mouse SMG

10

salivary gland development involves the interaction of multiple ___ types

cell

11

future studies are necessary to understand what 3 things in salivary gland development?

  • what dictates the position of the glands
  • how a cell becomes mucus or serous
  • how individual cell types contribute to gland formation

12

L1 peptide-conjugated fibrin hydrogels promote ___

salivary gland regeneration

13

there is a rich level of active caspase-3 and survivin within the lumen of the salivary gland at the ___ stage

canalicular

14

in the canalicular stage, terminal acinal cells have ___; this is how you can tell they are terminal cells

mucins

15

___ levels are high in the terminal bud stage

EGF

16

salivary glands continue developing in mice about how long after birth?

4 weeks

17

which stage of human salivary gland development is depicted?

prebud stage

18

which stage of human salivary gland development is depicted?

initial bud stage

19

which stage of human salivary gland development is depicted?

canalicular stage

20

describe afferent and efferent signals in salivary gland innervation

21

when does the location of parasympathetic and sympathetic innervation develop in salivary glands?

  • parasympathetic - at the same time as the gland
  • sympathetic - post-natal (P3-P5)

22

what is the parasympathetic neurotransmitter release in salivary glands?

acetylcholine is released either from the otic ganglion (innervates parotid) or from the submandibular ganglion (innervates the SMG and SL)

23

what is the sympathetic neurotransmitter release of salivary glands?

noepinephrine is released by efferent nerves arising from the superior cervical ganglion away from the gland in the thoracic spinal cord

24

during what stage of development can aplasia of lacrimal and salivary gland occur?

pre-bud to initial bud stage

25

during what stage can lacrimoauriculodentodigital syndrome occur?

initial bud to pseudoglandular stage

26

during what stage can hypohidrotic ectodermal displasia occur?

canalicular stage