QUIZ 3 Dentin Pulp Complex I Flashcards Preview

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Flashcards in QUIZ 3 Dentin Pulp Complex I Deck (102)
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1

dentin is the main ___ material of the tooth

structural

2

the structure of the dentin is directly linked to what?

its primary function of supporting tooth loading

3

briefly describe enamel, dentin, and pulp 

  • enamel
    • mineralized protective component
  • dentin
    • mineralized structural component
  • pulp
    • main cellular component

4

dentin is highly analogous to ___, but slightly different composition and highly different anatomy

bone

5

the crown is covered by ___, and the root is covered by ___

  • enamel
  • cementum

6

dentin is ___% inorganic material, ___% organic material, and ___% water

70%, 20%, 10%

7

hydroxyapatite makes up the ___ component of dentin

inorganic material

8

what is the formula for hydroxyapatite, and how many molecules of HA are in each crystal unit cell?

Ca5(PO4)3(OH)

2 per crystal unit cell

9

HA is effectively a ___ ___ crystal

calcium phosphate

10

fluoride can replace the ___ in hydroxyapatite, creating ___

  • OH
  • fluoroapatite

11

besides fluoride, what else can replace the OH in hydroxyapatite in dentin?

zinc, magnesium, and others

12

in dentin, HA crystals are what shape?

flattened rectangular plates

13

what are the dimensions of HA in dentin?

  • 60-70 nm long
  • 20-30 nm wide
  • 3-4 nm thick

14

dentin is somewhat harder than ___.  what are the knoop numbers for dentin, enamel, and bone?

  • bone
  • knoop numbers:
    • dentin - 68
    • enamel - 343
    • cortical bone - 50

15

what is the composition of the organic material component of dentin?

  • 90% collagen
    • mostly I, some III and V
  • 10% non-collagenous proteins

16

describe the collagen component of the organic component of dentin

  • 90%
  • mostly collagen I, some III and V
  • fibrillar collagen scaffold upon which HA crystals are laid down

17

what are the 5 non-collagenous proteins that dentin has in common with bone?

  • bone sialoprotein (BSP)
  • osteopontin (OP)
  • osteocalcin (OC)
  • osteonectin (ON)
  • matrix extracellular phosphoglycoprotein

18

what are the 2 main dentin specific non-collagenous proteins?

  • dentin matrix protein-1 (DMP-1)
  • dentin sialophosphoprotein (DSPP)
  • *still found in bone, but only trace amounts

19

DSPP can be further cleaved into what 3 functional proteins?

  • dentin sialoprotein (DSP)
  • dentin phosphoprotein (DPP)
  • dentin glycoprotein (DG)

20

DSPP is cleaved rapidly by what enzyme?

BMP-1

21

describe DSP

  • proteoglycan
  • expressed in dentinal tubules
  • may act to prevent mineralization
  • similar to DMP-1

22

describe DGP

  • glycoprotein
  • role in biomineralization?
  • unknown function

23

describe DPP

  • binds lots of calcium, initiates HA formation
  • attached to collagen
  • not thought to be glycosylated

24

DSP comes from which end of DSPP?

N terminus

25

DPP comes from which end of DSPP?

C terminus

26

defects in DSPP can cause what?

dentinogenesis imperfecta types II and III

27

which dentinogenesis imperfecta type is described by the following:

results from OI (defect in collagen I), pulp chambers filled with abnormal dentin

type I (not a result of defects in DSPP)

28

which dentinogenesis imperfecta type is describe by the following?

not associated with osteogenesis imperfecta (DSPP defect), pulp chambers filled with abnormal dentin

type II

29

which dentinogenesis imperfecta type is describe by the following?

enlarged pulp chambers, hypo-mineralization, possibly failure of DSPP expression

type III

30

dentin is synthesized by ___, which line the pulp chamber

odontoblasts