RA/Gout not covered in sketchy Flashcards Preview

Pharm > RA/Gout not covered in sketchy > Flashcards

Flashcards in RA/Gout not covered in sketchy Deck (40)
Loading flashcards...
31

Major side effects of sulfasalazine?

Hepatotoxicity; agranulocytosis (rare)

32

Which biologics increase risk of infection?

All
(all probably cause increased risk malignancy as well)

33

What is the MoA for Hydroxychloroquine?

Inhibits:
a) TLR signaling
b) Antigen presentation

34

Which DMARDs/biologics would you use to treat mild RA sx?
Mod?
Severe?

Mild: hydroxychloroquine or sulfasalazine (or combo of them)
Mod: MTX (alt: leflunomide)
Severe: MTX + a biologic

35

Which 2 DMARDs are often combined together?

Hydroxychloroquine and sulfasalazine

36

Which of the biologics and DMARDs are contraindicated in pregnancy?

DMARDs: Methotrexate, leflunomide
Biologics: none

37

Besides increasing risk of infection, what side effects can entanercept, adlimumab, and infliximab cause?

Rare: Exacerbates CHF. Increase risk demyelinating disease.
Increased risk malignancy.

38

Which anti-RA drugs cause an increased risk of malignancy?

DMARDs: MTX
Biologics: all except abatacept, rituximab

39

Which DMARD can cause agranulocytosis?

Sulfasalazine

40

Which of the DMARDs and biologics cause bone marrow suppression?

DMARDs: MTX
Biologics: Anakinra, tocilizumab, tofactinib