Flashcards in RA/Gout not covered in sketchy Deck (40)
Major side effects of sulfasalazine?
Hepatotoxicity; agranulocytosis (rare)
Which biologics increase risk of infection?
(all probably cause increased risk malignancy as well)
What is the MoA for Hydroxychloroquine?
a) TLR signaling
b) Antigen presentation
Which DMARDs/biologics would you use to treat mild RA sx?
Mild: hydroxychloroquine or sulfasalazine (or combo of them)
Mod: MTX (alt: leflunomide)
Severe: MTX + a biologic
Which 2 DMARDs are often combined together?
Hydroxychloroquine and sulfasalazine
Which of the biologics and DMARDs are contraindicated in pregnancy?
DMARDs: Methotrexate, leflunomide
Besides increasing risk of infection, what side effects can entanercept, adlimumab, and infliximab cause?
Rare: Exacerbates CHF. Increase risk demyelinating disease.
Increased risk malignancy.
Which anti-RA drugs cause an increased risk of malignancy?
Biologics: all except abatacept, rituximab
Which DMARD can cause agranulocytosis?