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Flashcards in RBF and GFR Deck (31)
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1

What are Tamm Horsfall protein

most abundant protein in urine, sign of stones, make in thick LoH

2

what would filter fastest

small and positively charged molecule

3

what does damaged filtration barrier cause?

larger and more negative things are getting through

4

what causes damaged filtration barrier

hematuria, diabetic nephropathy, minimal change disease, nephropathy

5

what is P_uf

capillary ultrafiltration pressure but it really is the net filtration pressure

6

what affects P_gc

Renal A BP, afferent arteriole resistance, efferent arteriole resistance

7

how do you calculate the ultrafiltration coefficient

hydraulic conductivity (L_p) x surface area (S_f)

8

Constricting the afferent arteriole does what for filtration pressure and GFR

decrease; decrease

9

constricting the efferent arteriole does what for filtration pressure and GFR

increase; increase

10

dilating the afferent arteriole does what for filtration pressure and GFR

increase; increase

11

dilating the efferent arteriole does what for filtration pressure and GFR

decrease; decrease

12

as O2 consumption goes up, what does Na reabsorption do

increases

13

what side is more affected by sympathetic

afferent; alpha 1 receptors

14

what are the vasoconstrictors we are looking at

-catecholamines (NE and epi)
-Ang II
-Endothelin

15

what vasodilators are we concerned with

•PGE 2
•PGI 2
•Nitric oxide
•Bradykinin
•Dopamine
•Atrial natriuretic peptide

16

what is the autoregulatory range of the kidney

80-170 mm Hg

17

what are the two ways that the kidneys autoregulate BP

local reflex (myogenic)
physiologic feed back (juxtaglomerular cells)

18

myogenic feedback manifests as changes in what? what is responsible

afferent arteriole constriction and efferent arteriole dilation; Ca++

19

juxtaglomerular cells

secrete renin

20

macula densa

senses NaCl in DCT

21

mesangial cells

contraction

22

increased delivery of NaCl to macula densa does what

increases ATP (think adenosine) then vasoconstricts afferent arteriole which decreases GFR anf RBF

23

decreased delivery of NaCl to macula densa does what

macula densa tells JG cells to secrete renin, efferent vasoconstriction, and releases NO to afferent causing dilation

24

What increases the sensitivity of TGF (tubuloglomerular feedback)

•Volume contraction
•Adenosine
•PGE 2
•Thromboxane
•Ang II

25

what decreases sensitivity of TGF

•Volume expansion
•ANP
•NO
•cAMP
•PGI 2
•High-protein diet*

26

what effect does afferent vasodilation have on RBF, GFR, and peritubular capillary hydrostatic pressure

increase; increase; increase

27

what does afferent vasoconstriction do to RBF, GFR, and peritubular capillary hydrostatic pressure

decrease; decrease; decrease

28

what does efferent vasodiltion cause to RBF, GFR, and peritubular capillary hydrostatic pressure

increase, decrease, increase

29

what causes efferent arteriole vasodilation

sympathetics

30

what effect does efferent vasoconstriction have on RBF, GFR, peritubular capillary hydrostatic pressure

increase; increase or same; decrease