Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

2ND SEM BIOCHEMISTRY > [RECALLS] Heme, Porphyrins And Nucleotides > Flashcards

[RECALLS] Heme, Porphyrins And Nucleotides Flashcards

(80 cards)

Start Studying
1
Q

5th coordinating carbon of myoglobin is linked to:

A

His F8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

6th coordinating carbon of myoglobin is linked to:

A

His F7

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Fetal hemoglobin

A

Alpha 2

Gamma 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

All are true of myoglobin except

A

Releases O2 when PO2 of muscles decrease to 20 mmHg during strenous exercise

*It should be 5 mmHg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hemoglobinopathy where in His F8 is replaced by tyrosine

A

Hemoglobin M

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Oxygen dissociation curve of myoglobin

A

Hyperbolic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Oxygen dissociation curve of hemoglobin

A

Sigmoidal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Condition wherein alpha or beta globin chains are absent or decreased in number

A

Thalassemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

O2 binds to hemoglobin tetramer more readily if other O2 molecules are already bound

A

Cooperative binding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Largest repository of heme

A

RBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Heme iron is ferric

A

Methemoglobinemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In cooperative binding

A

Iron is slightly out of place secondary to sterric repulsion between proximal His and N atoms or porphyrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Reciprocal coupling of proton and O2 binding

A

Bohr effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Iron oxidized to ferric form

A

Hemin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Iron lie outside the plane of heme

A

Deoxygenated hemoglobin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which of the following is true

A

Unoxygenated myoglobin iron lies outside the heme ring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Low PO2

A

Synthesis of 2,3 BPG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Direct measure of the activity of heme oxygenase

A

CO of expired air

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Heme coordination process except

A

Carboxylation and decarboxylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which are colorless compounds

A

Porphyrinogens (Urobilinogens)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Porphyrin ring

A

Hyrophobic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Bilirubin in bile

A

Conjugated bilirubin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Blue-green color

A

Biliverdin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Albumin

A

Left in plasma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Location of heme oxygenase
Endoplasmic reticulum
26
Conjugation of bile catalyzed by
UDP glucoronyl transferase
27
Has large capacity that even under the pathologic conditions, transport does not appear to be rate-limiting for metabolism of bilirubin
Facilitated transport system
28
Derivatives of purine and the pyrimidine that has a sugar inked to a ring N
Nucleosides
29
Sugar is linked to the heterocyclic base via:
B, N-glycosidic bond
30
Which is true of sugar that is linked to a heterocyclic base:
N-1 pyrimidine | N-9 purine
31
Nucleoside with a phosphoryl group esterified to a hydroxyl group of the sugar
Mononucleosides
32
Utilized in transfer of formy-group 1
N10-formyl-tetrahydrofolic acid
33
Nucleoside with an attached phosphate group
Monophosphate
34
Free nucleotides (intermediates in the catabolism of adenine and guanine)
Xanthine, hypoxanthine, uric acid
35
What permits purines and pyrimidines to function as group transfer reagents?
Nucleoside triphosphates have high group transfer potential
36
Nucleoside derivative of guanine
Guanosine
37
Nucleoside derivative of adenine
Adenosine
38
Nucleoside derivative of uracil
Uridine
39
Hydrogen atom attached to #2 carbon
Deoxyribose
40
True about P450 except
PO2 half saturates myoglobin
41
Most compact representation with the 5’ end on the left
Base sequence
42
Fetal hemoglobin
Alpha 2 | Gamma 2
43
All are true of myoglobin except
Releases O2 when PO2 of muscles decrease to 20 mmHg during strenous exercise *It should be 5 mmHg
44
Hemoglobinopathy where in His F8 is replaced by tyrosine
Hemoglobin M
45
Oxygen dissociation curve of myoglobin
Hyperbolic
46
Oxygen dissociation curve of hemoglobin
Sigmoidal
47
Condition wherein alpha or beta globin chains are absent or decreased in number
Thalassemia
48
O2 binds to hemoglobin tetramer more readily if other O2 molecules are already bound
Cooperative binding
49
Largest repository of heme
RBC
50
Heme iron is ferric
Methemoglobinemia
51
In cooperative binding
Iron is slightly out of place secondary to sterric repulsion between proximal His and N atoms or porphyrin
52
Reciprocal coupling of proton and O2 binding
Bohr effect
53
Iron oxidized to ferric form
Hemin
54
Iron lie outside the plane of heme
Deoxygenated hemoglobin
55
Which of the following is true
Unoxygenated myoglobin iron lies outside the heme ring
56
Low PO2
Synthesis of 2,3 BPG
57
Direct measure of the activity of heme oxygenase
CO of expired air
58
Heme coordination process except
Carboxylation and decarboxylation
59
Which are colorless compounds
Porphyrinogens (Urobilinogens)
60
Porphyrin ring
Hyrophobic
61
Bilirubin in bile
Conjugated bilirubin
62
Blue-green color
Biliverdin
63
Albumin
Left in plasma
64
Location of heme oxygenase
Endoplasmic reticulum
65
Conjugation of bile catalyzed by
UDP glucoronyl transferase
66
Has large capacity that even under the pathologic conditions, transport does not appear to be rate-limiting for metabolism of bilirubin
Facilitated transport system
67
Derivatives of purine and the pyrimidine that has a sugar inked to a ring N
Nucleosides
68
Sugar is linked to the heterocyclic base via:
B, N-glycosidic bond
69
Which is true of sugar that is linked to a heterocyclic base:
N-1 pyrimidine | N-9 purine
70
Nucleoside with a phosphoryl group esterified to a hydroxyl group of the sugar
Mononucleosides
71
Utilized in transfer of formy-group 1
N10-formyl-tetrahydrofolic acid
72
Nucleoside with an attached phosphate group
Monophosphate
73
Free nucleotides (intermediates in the catabolism of adenine and guanine)
Xanthine, hypoxanthine, uric acid
74
What permits purines and pyrimidines to function as group transfer reagents?
Nucleoside triphosphates have high group transfer potential
75
Nucleoside derivative of guanine
Guanosine
76
Nucleoside derivative of adenine
Adenosine
77
Nucleoside derivative of uracil
Uridine
78
Hydrogen atom attached to #2 carbon
Deoxyribose
79
True about P450 except
PO2 half saturates myoglobin
80
Most compact representation with the 5’ end on the left
Base sequence

2ND SEM BIOCHEMISTRY (33 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions