[RECALLS] Intracellular traffic and sorting of proteins

Question 1

Cystolic chaperone to prevent misfolding

Answer 1

Hsp 70

Question 2

Chaperone system that ensures proper folding

Answer 2

Hsp 60

Question 3

The transport of nucleus to cytoplasm is bidirectional and occurs through:

Answer 3

Nuclear pore complex

Question 4

After interaction of unfoled protein to Hsp 70 with mitochondrial TOM20/22, they are transferred to what channel?

Answer 4

TOM40

Question 5

CHON formed in the translocation of the majority of mRNA molecule through NPC which does not include Ran use:

Answer 5

Hydrolysis of ATP by a DBPS to drive translocation

Question 6

Organelle responsible for metabolizing hydrogen peroxide

Answer 6

Peroxisome

Question 7

Second major clas of chaperones that form band-like structures where unfolded protein is retained

Answer 7

Chaperonins

Question 8

True about chaperones

Answer 8

Many hare heat shock proteins

Question 9

Shuffling of disulfide bonds

Answer 9

Disulfide isomerase

Question 10

COP1 transfer

Answer 10

GA to ER (Retrograde)

Question 11

Plays a critical regulatory role in the interaction of the complex with the NPC and its translocation through it

Answer 11

Ran

Question 12

Proteins that misfold in the ER are transported back across ER by

Answer 12

Proteosomes

Question 13

An important organelle involved in metabolism of many molecules including fatty acids and other lipids, purines, amino acids and hydrogen peroxide

Answer 13

Peroxisome

Question 14

The condition apparent at birth and is characterized by profound neurological impairment

Answer 14

Zellweger syndrome

Question 15

Hydrostatic pressure of arteriole

Answer 15

37 mmHg

Question 16

COP I

Answer 16

Retrograde transport (Golgi to ER)

Question 17

COP II

Answer 17

Anterograde transport (ER to Golgi)

Question 18

Passage through the two membranes (outer and inner mitochondrial membranes)

Answer 18

Translocation

Question 19

True of signal peptide

Answer 19

Contains at least one positively charged amino acid near their amino terminal

Question 20

Transport from nucleus to cytoplasm

Answer 20

NPC

Question 21

True of nuclear pore complex

Answer 21

Transport is bidirectional

Question 22

ER to Golgi apparatus, involved in export from the ER to either ERGIC or the GA

Answer 22

COP II

Question 23

Number of ubiquinated molecules

Answer 23

4