Renal QBank Flashcards Preview

Boards > Renal QBank > Flashcards

Flashcards in Renal QBank Deck (13):
1

Bilateral Angiomyolipoma cause

Tuberous sclerosis

2

Transplant Tx

Cyclosporine or Tacrolimus inhibit (calcineurin -> IL-2 -> T lymphocytes)

3

Bcl-2

Apoptosis inhibitor
-Overexpressed in follicular cell lymphoma (t(14;18) translocation)

4

Neurofibromin

Tumor suppressor protein (NF-1 gene)
-suppresses Ras

5

NSAIDs on kidney

Afferent constriction

6

ACE-I on kidney

Efferent constriction

7

Angiotensin effect

-Systemic vasoconstriction
-Efferent glomerular arteriole constriction (decrease GFR)
-Enhanced adrenal cortical aldosterol secretion

8

Vasopressin MOA

V-R mediated increase inner medullary collecting duct permeability to water and urea (more collection)

9

Aspirin toxicity

First - Respiratory alkalosis (medulla stimulation -> hyperventilation)
Hours later - Metabolic acidosis

10

Amphotericin B effect on kidney

acute tubular necrosis
-Hypokalemia
-Hypomagnesemia

11

Renal oncocytoma

Rare collecting duct cancer
-Numerous mitochondria

12

Transitional cell carcinoma

Renal pelvis
-Papillary tumors (w/stalk)

13

Renal clear cell carcinoma

Proximal renal tubules
-Polygonal cells with abundant cytoplasm
-Golden yellow on gross examination