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Flashcards in Repro drugs Deck (36):
1

Leuprolide mechanism

GnRH analog

2

use: leuprolide

1. infertility (give pulsatile)
2. prostate cancer, prostate cancer, uterine fibroids, precocious puberty (continuous)

3

tox leuprolide

antiandrogen, N/V

4

testosterone use:

hypogonadism
burn victims

5

effect of testosterone on LDL and HDL

increase LDL
Decrease HDL

6

finasteride mech

5a reductase inhibitor

7

use of finasteride

BPH
hair growth

8

flutamide mechanism

competitive inhibitor of androgens at testosterone receptor

9

use: flutamide

prostate carcinoma

10

ketoconazole mechanism

inhibits steroid synthesis thru desmolase

11

spironolactone mech

blocks testosterone binding

12

use: ketoconazole and spironolactone

Hirsutism in PCOS

13

DES and mestranol

estrogens

14

mech clomiphene

estrogen partial agonist blocking feedback inhibition. Increase in LH/FSH=ovulation

15

tox clomiphene

hot flashes, multiple pregnancies
ovarian enlargement
visual disturbances

16

tamoxifen mechanism

estrogen antagonist on breast tissue

17

use: tamoxifen

ER positive breast cancers

18

raloxifene mechanism

1. bone estrogen agonist
2. estrogen antagonist elsewhere

19

indication for raloxifene

osteoporosis

20

tox HRT

endometrial cancer possibly CV risk

21

what do we add to estrogen in HRT to reduce risk of endometrial cancer

progesterone

22

anastrozole/exemestane mechanism

aromatase inhibitors in postmenopausal women with breast cancer

23

use: progestins

endometrial cancer
abnormal uterine bleeding

24

mifepristone mechanism

competitive inhibitor of progestins

25

use: Mifepristone

termination of pregnancy with misoprostol (PGE1)

26

mechanism OCP

Inhibition of LH/FSH and no estrogen surge
=no LH surge
THickening of cervical mucus

27

terbutaline mechanism

B2 agonist
--relaxes uterus

28

use: terbutaline

reduces premature uterine contractions

29

tamsulosin mechanism

a1 antagonist selective for prostate receptors a1AD

30

use: tamsulosin

BPH

31

sildenafil mechanism

inhibits phosphodiesterase 5, increasing cGMP
--relaxing smooth muscle

32

tox of sildenafil

headache, hot, heartburn
Impaired blue/green vision

33

sildenafil contraindicated in

pts taking nitrates
--LIFE THREATENING HYPOTENSION

34

Danazol mechanism

Synthetic androgen
--Partial agonist at androgen receptors

35

Use danazol

endometriosis and hereditary angioedema

36

tox of danazol

weight gain
edema
acne
masculinization
HEPATOTOX
low HDL