Microbio Flashcards Preview

Random boards stuff > Microbio > Flashcards

Flashcards in Microbio Deck (17):
1

Mechanism of metronidazole

Unravels DNA and breaking strands

2

Mechanism of bacitracin

Prevents mucopeptide transfer into growing cell wall

3

Mechanism of sulfamethoxazole

Compete with PABA to inhibit DHF synthesis, an intermediate step

4

What can you do to increase the plasma concentration of imipenem?

Coadminister cilastatin. Prevents renal metabolism of imipenem.

5

Two mechanisms of penicillin resistance

1. beta lactamases
2. modification of penicillin binding proteins (MRSA does this to resist nafcillin, oxacillin)

6

Cycloserine mechanism

Inhibits incorporation of DAla during cell wall synthesis. BUT high ototoxicity rarely used.

7

Mechanism of polymyxin

binds to and disrupts permeability of cytoplasmic membrane

8

Mechanism of resistance to aminoglycosides

inactivation by a modifying enzyme. These will phosphorylate/adenylate/acetylate the antibiotic.

9

mechanism of daptomycin

depolarizes cellular membrane by creating transmembrane channels

10

side effect daptomycin

myopathy+CPK elevation
inactivated by pulmonary surfactant

11

Linezolid mechanism

inhibits bacterial protein synthesis by binding 50S subunit

12

Side effects linezolid

thombocytopenia and optic neuritis

13

side effect of vancomycin

red man syndrome nephrotoxicity

14

penicillins are structural analogs of

D-Ala-D-Ala

15

Sulfonamide mechanism

competes with PABA for incorporation into folic acid

16

Condyloma lata

wart like genital lesion that shows up during secondary syphilis

17

tertiary syphilia

Gummas (necrotizing granulomas on skin), with neuro sx, cardiovascular involvement. If neuro sx, the lesion has to be a gumma!