Flashcards in Microbio Deck (17):
Mechanism of metronidazole
Unravels DNA and breaking strands
Mechanism of bacitracin
Prevents mucopeptide transfer into growing cell wall
Mechanism of sulfamethoxazole
Compete with PABA to inhibit DHF synthesis, an intermediate step
What can you do to increase the plasma concentration of imipenem?
Coadminister cilastatin. Prevents renal metabolism of imipenem.
Two mechanisms of penicillin resistance
1. beta lactamases
2. modification of penicillin binding proteins (MRSA does this to resist nafcillin, oxacillin)
Inhibits incorporation of DAla during cell wall synthesis. BUT high ototoxicity rarely used.
Mechanism of polymyxin
binds to and disrupts permeability of cytoplasmic membrane
Mechanism of resistance to aminoglycosides
inactivation by a modifying enzyme. These will phosphorylate/adenylate/acetylate the antibiotic.
mechanism of daptomycin
depolarizes cellular membrane by creating transmembrane channels
side effect daptomycin
inactivated by pulmonary surfactant
inhibits bacterial protein synthesis by binding 50S subunit
Side effects linezolid
thombocytopenia and optic neuritis
side effect of vancomycin
red man syndrome nephrotoxicity
penicillins are structural analogs of
competes with PABA for incorporation into folic acid
wart like genital lesion that shows up during secondary syphilis