rheum

Question 1

What do Anti-CCP antibodies indicate in rheumatoid arthritis?

Answer 1

A marker of poor prognosis

Anti-CCP stands for Anti-Cyclic Citrullinated Peptide antibodies, which are often present in patients with rheumatoid arthritis.

Question 2

Imaging for AVN of hip?

Answer 2

MRI

Question 3

What is McArdle’s disease?

Answer 3

A glycogen storage disorder characterized by repeated cramping, rhabdomyolysis, and myoglobinuria after exercise.

McArdle’s disease is linked to impaired energy metabolism in skeletal muscle.

Question 4

What are the key symptoms of McArdle’s disease?

Answer 4

Repeated cramping, rhabdomyolysis, myoglobinuria after short bouts of exercise.

These symptoms occur due to impaired glycogen breakdown in muscle cells.

Question 5

What laboratory findings are associated with McArdle’s disease?

Answer 5

Marked elevations in CK and serum myoglobin.

These elevations indicate muscle damage and impaired energy metabolism.

Question 6

What enzyme deficiency causes McArdle’s disease?

Answer 6

Myophosphorylase deficiency.

Myophosphorylase is critical for glycogen breakdown in muscle cells.

Question 7

True or False: McArdle’s disease is caused by a deficiency in an enzyme involved in glycogen breakdown.

Answer 7

True.

The deficiency in myophosphorylase leads to the symptoms observed in McArdle’s disease.

Question 8

Fill in the blank: McArdle’s disease is a __________ storage disorder.

Answer 8

glycogen.

This disorder affects the metabolism of glycogen in muscle cells.

Question 9

What is the relationship between McArdle’s disease and exercise?

Answer 9

Symptoms such as cramping and rhabdomyolysis occur after short bouts of exercise.

This is due to the impaired ability to utilize glycogen for energy during physical activity.

Question 10

HLA B51 association?

Answer 10

Behcet’s disease

Question 11

HLA B27 association?

Answer 11

Ank spond

Question 12

HLA DQ2 association?

Answer 12

Coeliac disease

Question 13

HLA DR4 association?

Answer 13

Rheumatoid arthritis

Question 14

HLA DRB1 association?

Answer 14

SLE

Question 15

Antibodies associated with limited (central) systemic sclerosis?

Answer 15

Anti-centromere antibodies

Question 16

Anti-ds-DNA is diagnostic for?

Answer 16

Systemic lupus erythematosus (SLE)

Question 17

Anti-Scl-70 antibodies are specific for?

Answer 17

Diffuse scleroderma

Question 18

Signs of early and progressive disease in RA?

Answer 18

Early - juxta-articular osteoporosis/osteopenia
Progressive - peri-articular erosions

Question 19

Bone pain, tenderness and proximal myopathy (→ waddling gait)?

Answer 19

Osteomalacia

Question 20

The presence of anti-Ro antibodies in a pregnant patient with systemic lupus erythematosus leads to an increased risk of?

Answer 20

Congenital heart block (CHB) in the foetus

Question 21

Anti-Jo-1 antibody?

Answer 21

Dermatomyositis - ‘heliotrope’ rash, Gottron’s papules

Question 22

Osteogenesis imperfecta occurs due to an abnormality in which type of collagen?

Answer 22

Type 1

Question 23

Rheumatoid factor is positive and a diagnosis of rheumatoid arthritis is made. What is the most appropriate management to slow disease progression?

Answer 23

Methotrexate + short course of pred

Question 24

Inflammatory arthritis involving DIP swelling and dactylitis points to a diagnosis of? psoriatic arthritis

Answer 24

Psoriatic arthritis

Question 25

T score for osteopenia and osteoporosis?

Answer 25

Osteopenia -1.0 to -2.5 Osteoporosis -2.5 or lower

Question 26

Osteopetrosis is due to a defect in?

Answer 26

Osteoclasts

Question 27

Ehlers-Danlos syndrome is most commonly associated with a defect in which type of collageb?

Answer 27

Type 3

Question 28

Patients aged 75 and over with a history of fragility fractures should be considered for treatment with what drug and with/without requiring a DEXA scan?

Answer 28

Oral bisphosphonate without DEXA

Question 29

Looser's zones x-ray are most characteristically associated with which condition?

Answer 29

Osteomalacia

Question 30

De Q synovitis symptoms?

Answer 30

Inflammation of the sheath containing the extensor pollicis brevis and abductor pollicis longus tendons

Question 31

The most common cause of death in systemic sclerosis is?

Answer 31

Respiratory involvement

Question 32

Which TB drug can cause drug induced lupus?

Answer 32

Isonazid

Question 33

Normal Ca and PO4, raised ALP?

Answer 33

Pagets

Question 34

Arthralgia, salmon pink macpap rash, elevated ferritin, Rf and ANA negative?

Answer 34

Stills

Question 35

Familial Mediterranean fever (FMF) inheritance?

Answer 35

Auto recessive

Question 36

How to treat Paget's?

Answer 36

Bisphosphonates

Question 37

Child with swollen wrists and disturbance of the metaphyseal region on X-ray? Management?

Answer 37

Rickets - vitamin D

Question 38

Low calcium and phosphate, raised ALP and PTH?

Answer 38

Osteomalacia

Question 39

TNF-α inhibitors may?

Answer 39

Reactivate TB

Question 40

Second line if alendronate not tolerated?

Answer 40

Risedronate

Question 41

Fundoscopy reveals a swollen, pale optic disc with blurred margins in the right eye?

Answer 41

AION