Rheum / MSK

Question 1

PBC

Answer 1

Females
Pruritis, Xanthomas, Anti-Mitochondrial Abs

Question 2

PSC

Answer 2

p-ANCA Abs
Bile duct inflammation
IBD, Onion-skinnig

Question 3

Type I Auto-immune hepatitis

Answer 3

Young women
Anti-SM

Question 4

Type II auto-immune hepatitis

Answer 4

Kids
Anti-LKM

Question 5

Bullous Pemphigoid vs Vulgaris

Answer 5

Bullous: anti-HemiDesmosome, sub-epithelial
Vulgaris: +Mouth, anti-Desmosome

Question 6

Dermatitis Herpitiformis

Answer 6

Vesicles on anterior thigh
anti-BMZ
Anti-Endomysial

Question 7

Dermatomyositis

Answer 7

Anti-Jo-1
Myositis with a rash
Associated with occult malignancy

Question 8

Anti-GAD abs

Answer 8

DM 1

Question 9

Drug-Induced Lupus

Answer 9

Anti-Histone Ab
Hydralazine, INH, Phenytoin, Procainamide, Penicillamine, Ethosuximide

Question 10

Gastritis A

Answer 10

Anti-Parietal Cell Ab
Atrophic gastritis
Associated with Adenocarcinoma

Question 11

Goodpasture

Answer 11

Anti-GBM
Lung and kidney
Can progress to RPGN

Question 12

Hashimoto’s

Answer 12

Anti-Microsomal Ab

Question 13

ITP

Answer 13

Anti-Platelet Ab
Anti-GP2b3a

Question 14

Mixed connective tissue disease

Answer 14

Anti-RNP

Question 15

Membranoproliferative Glomerulonephritis II

Answer 15

Anti-C3 convertse (nephritic factor) Ab

Question 16

Paroxysmal hemolysis

Answer 16

Donath Landsteiner Ab
Bleed when cold

Question 17

Polyarteritis Nodosa

Answer 17

p-ANCA
Gut, kidneys, nervous system
Hep B association

Question 18

Post-Strep glomerulonephritis

Answer 18

ASO ab
Nephritic with compliment deposition
3 weeks post-infection

Question 19

Scleroderma

Answer 19

Anti-Scl70 (Topo 1)
Fibrosis, tight skin, Masked faces

Question 20

Sjogren’s

Answer 20

Anti-SSA
Increased NHL risk

Question 21

SLE

Answer 21

Anti-ds DNA / SM / Cardiolipin
Rheumatoid Factor+
False+ VRDL
FTA abs confirm

Question 22

SLE Cerebritis

Answer 22

Anti-Neuronal
Anti-Ribosomal

Question 23

Warm hemolysis

Answer 23

Anti-Rh
Bleeds at body temperature

Question 24

Wegner’s (GPA)

Answer 24

c-ANCA
ENT, Lungs, Kidney

Question 25

Berger's

Answer 25

IgA disease 2 weeks post-vaccine Serum Sickness (Buerger's is the finger necrosis w/ smoking thing)

Question 26

Alport's

Answer 26

IgA disease 2 weeks after diarrhea, HSP, Polio

Question 27

Myotonic Dystrophy

Answer 27

Birds beak face Can't let go when shaking hands

Question 28

Myasthenia Gravis

Answer 28

Anti-ACH postsynaptic Ab Get weaker as the day goes on Rule out Thymoma

Question 29

Lambert Eaton

Answer 29

Small Cell Lung CA Get stronger as the day goes on

Question 30

MS

Answer 30

Anti-Myelin Abs Vision disturbances, UMN, decreased sensation, wax and wane Each MS attack gets worse

Question 31

Metachromatic leukodystrophy

Answer 31

Arylsulfatase deficiency Child who presents like MS

Question 32

AT

Answer 32

IgA deficiency Spider veins

Question 33

Friedrich's Ataxia

Answer 33

Retinitis Pigments Scoliosis

Question 34

Adrenal Leukodystrophy

Answer 34

Broken Carnitine Shuttle (CAT-1) Adrenal Failure (X-Recessive) Long chain fatty acid stuck in cytoplasm

Question 35

Werdig-Hoffman

Answer 35

Fasciculations in a newborn Failure of anterior horns to develop

Question 36

Polio

Answer 36

Asymmetric fasciculations in kids 2 weeks after Gastroenteritis

Question 37

Choreoathetosis

Answer 37

Dance like movements, wringing of hands, quivering and unsteady hands

Question 38

Atonic cerebral palsy

Answer 38

No muscle tone, floppy

Question 39

Seborrheic keratosis

Answer 39

Tan-brown-black stuck on appearance

Question 40

Stucco keratoses

Answer 40

Barnacles White-flesh colored stuck on papules

Question 41

Dermatosis papulosa nigra

Answer 41

Variant of SK on the face, neck of dark-skinned people

Question 42

Keratoacanthoma

Answer 42

smooth, dome-shaped, red papule Central filled keratin crater Precursor to SCC

Question 43

Epidermal nevus

Answer 43

hamartomas that follow Blaschkos lines

Question 44

Syringomas

Answer 44

Sweat duct tumor on lower eyelid

Question 45

Erysipelas

Answer 45

Superficial cellulitis along lymph channel

Question 46

Woods light

Answer 46

Tinea versicolor Tuberous Sclerosis Helps see HYPO-pigmented lesions

Question 47

Tinea Versicolor

Answer 47

Pityrosporum KOH prep spaghetti and meatballs

Question 48

Leishmaniosis

Answer 48

Protozoan from Sandflies Painless ulcer with central crater

Question 49

Molluscum contagiosum cause

Answer 49

POXVIRUS

Question 50

Dew drop on rose petal

Answer 50

Varicella / Chickenpox HHV3

Question 51

Cafe au lait spots

Answer 51

NF1 and McCune Albright

Question 52

HLA-B27

Answer 52

Ankylosing Spondylitis Psoriatic, Enteropathic, Reactive Arthritis

Question 53

HLA-DR4

Answer 53

Rheumatoid Arthritis

Question 54

HLA-C

Answer 54

Psoriasis

Question 55

HLA-DQ2/8

Answer 55

Celiac

Question 56

HLA-B8

Answer 56

MG

Question 57

HLA-A3

Answer 57

Homochromoatosis

Question 58

Leg cutaneous nerve roots

Answer 58

Back, around to lateral foot: S1 (between L5-S1) Medial foot and leg, across thigh: L4 Middle of foot, lateral leg: L5

Question 59

C5

Answer 59

Biceps reflex, deltoid sensation, forearm flexion

Question 60

C6

Answer 60

Brachioradialis reflex Lateral forearm and first 2 digit sensation Wrist extionsion, bicep flexion

Question 61

C7

Answer 61

Tricep reflex Middle finger sensation Arm extionsion, wrist flexion

Question 62

C8

Answer 62

4-5 digit and medial forearm sensation Finger flexion

Question 63

T1

Answer 63

Medial aspect of arm sensation intercostal motor

Question 64

Treat Sjogrens

Answer 64

Mild: Secreatagogues (Civemiline, pilocarpine) Systemic: Glucocorticoids Severe: HCQ, DMARDs

Question 65

Treat Celiac associated dermatitis herpitiformis

Answer 65

Dapson and d/c gluten