Flashcards in Rheumatoid Arthritis Deck (17):
What is rheumatoid arthritis?
(What is it, whats its distribution, what does it effect?)
Chronic autoimmune systemic illness characterised by a symmetrical peripheral arthritis and other systemic symptoms
If rheumatoid arthritis goes untreated what 3 things can it be associated with?
Is rheumatoid more likely with one joint effected, a couple of joints or many joints?
What duration of symptoms make rheumatoid arthritis more common?
6 weeks or more
What is the epidemiology of rheumatoid arthritis?
-Approx 1% of pop
M:F -> 1:3
Age of onset:
-Peak age 4th/5th decade but may occur at any age from 16 years
What is the aetiology of rheumatoid arthritis?
-Chronic infection (e.g. periodontal disease)
What is the pathology of rheumatoid arthritis?
-inflammed synovial membrane
-thinning of cartilage
-inflammatory cell infiltration
What serology tests can you do in rheumatoid arthritis?
Rheumatoid factor (IgG, IgM)
Anti Cyclic Citrullinated Antibodies (anti CCP, ACPA)
What imaging studies can you use in rheumatoid arthritis investigation?
-Joint space narrowing
-Destruction of bones around joint
What are the symptoms of arthritis?
What are the clinical signs of arthritis?
Limitation of movement
Where does joint pain usually occur first in rheumatoid arthritis?
Distal small joints
-(hands and feet)
What are the systemic features of rheumatoid arthritis?
(non-specific, specific and long term)
How common are rheumatoid nodules?
Up to 20% of patients will have them.
May indicate worse disease
How can you assess the activity of rheumatoid arthritis?
(any scoring system?)
Disease Activity Score
What DAS score represents eligibility for biologic therapy?