Rheumatoid Arthritis Flashcards Preview

MSK Anatomy > Rheumatoid Arthritis > Flashcards

Flashcards in Rheumatoid Arthritis Deck (17):
1

What is rheumatoid arthritis?

(What is it, whats its distribution, what does it effect?)

Chronic autoimmune systemic illness characterised by a symmetrical peripheral arthritis and other systemic symptoms

2

If rheumatoid arthritis goes untreated what 3 things can it be associated with?

Joint damage
Disability
Premature mortality

3

Is rheumatoid more likely with one joint effected, a couple of joints or many joints?

Polyarteritis

4

What duration of symptoms make rheumatoid arthritis more common?

6 weeks or more

5

What is the epidemiology of rheumatoid arthritis?

Prevalence:
-Approx 1% of pop

M:F -> 1:3

Age of onset:
-Peak age 4th/5th decade but may occur at any age from 16 years

6

What is the aetiology of rheumatoid arthritis?

Genetic

Environmental
-Smoking
-Chronic infection (e.g. periodontal disease)

7

What is the pathology of rheumatoid arthritis?

Synovitis
-inflammed synovial membrane
-thickening
-thinning of cartilage
-inflammatory cell infiltration

8

What serology tests can you do in rheumatoid arthritis?

Rheumatoid factor (IgG, IgM)

Anti Cyclic Citrullinated Antibodies (anti CCP, ACPA)

9

What imaging studies can you use in rheumatoid arthritis investigation?

X-ray
-Joint space narrowing
-Joint errosion
-Destruction of bones around joint

Ultrasound Doppler
-Shows inflammation

10

What are the symptoms of arthritis?

Pain
Stiffness
Immobility
Poor function
Systemic Symptoms

11

What are the clinical signs of arthritis?

Swelling
Tenderness
Limitation of movement
(Redness)
(Heat)

12

Where does joint pain usually occur first in rheumatoid arthritis?

Distal small joints
-(hands and feet)
-symmetrical

13

What are the systemic features of rheumatoid arthritis?

(non-specific, specific and long term)

Non-specific
-Fatigue
-Weight loss
-Anaemia

Specific
-Eyes
-Lungs
-Nerves
-Skin
-Kidneys

Long term
-CVS, malignancy

14

How common are rheumatoid nodules?

Up to 20% of patients will have them.

May indicate worse disease

15

How can you assess the activity of rheumatoid arthritis?

(any scoring system?)

Disease Activity Score
(DAS 28)

16

What DAS score represents eligibility for biologic therapy?

>5.1

17

What DAS score represents clinical remission?