Flashcards in Serology and Lab Testing - Johnston Deck (44)
Diagnostic labs for arthritis (7)
- ASOT (anti-streptolysin titer)
- Uric acid
RF + Anti-CCP = ____
RA (99.5% confidence)
ANA - means what alone?
Little - many people have them
ASOT - means what?
Previous streptococcal infection
List of acute phase reactants (7)
Which one is higher in women?
Also higher in who?
Diseases that this is especially good for? (2)
Polymyalgia rheumatica, giant cell arteritis
CRP is a good marker for ___
Any inflammation (pro-inflammatory cytokines)
Activates complement, promotes phagocytosis
**CRP vs. ESR levels over time
CRP -- rises and falls faster than ESR
CRP > ___ = inflammatory
RF is MOST commonly what?
Produced by what?
IgM -- against Fc of IgG
B cells in synovial joints
Patients with _____ will 100% have RF antibodies
RA subQ nodules
Other autoimmune diseases that can have RF
Sjogrens, SLE, Cryoglobulinemia, Primary Biliary Cirrhosis, MCT disease, Endocarditis, Sarcoidosis, malignancy
Patients w/ RF are most likely to have what antibody?
Aggressive, erosive disease
Homogenous pattern of ANA immunofluorescence
Which ones? (3)
Phenytoin, Procainamide, Hydralazine
Criteria for SLE (11)
Oral/nasal ulcers - painless
Arthritis - 2+ peripheral joints
Serositis - pleuritis, pericarditis
Neurologic issue - seizure/psych
Renal issue - proteinuria or casts
***Blood disorder - HA + reticulocytosis, low WBC (under 4000), low platelets (under 100,000)
Immunologic issue - antibodies
False positive RPR (test for syphilis)
Previous Group A strep infection
Acute rheumatic fever - criteria
- Joints (arthritis)
- Nodules (subQ)
- Erythema marginatum
- Sydenham chorea
Digital radiography is good for looking at what?
Joint erosions, osteopenia, etc.
Ultrasonography is good for looking at what?
Aid in doing what?
Soft tissue abnormalities - synovitis, tendonitis, bursitis
MRI is good for what?
Don't use Gadolinium if...?
Soft tissue abnormalities - spine, SI, synovitis, tenosynovitis, erosions
Kidney disease - will cause nephrogenic systemic fibrosis
CT is good for what?
Bony abnormalities, erosions, fractures, degenerative or inflammatory arthritis
Pitting of nails
Hepatitis, Mono, Syphilis, Strep
Discoid plaques on face
Inflamed gut + sores in mouth + sores in genitals
Reactive arthritis - bugs
Clubbing + arthritis + pulmonary disease
Hypertrophic pulmonary osteoarthritis (HPO)
Nodules in lungs + arthritis
RA, Wegeners, Paraneoplastic
Hilar nodes + arthritis
Pulmonary infiltrates + arthritis
DM -- Neuropathic degeneration and distortion of a joint
DM -- Thickened skin, limited joint mobility of hands and fingers, causing flexion contractures
Hypothyroidism can present with what?
Carpal/Tarsal Tunnel Syndrome
Arthritis + conjunctivitis
Arthritis + iritis
SNSA, Lyme, JRA, Sarcoid
Arthritis + lacrimal enlargement
Arthritis + xerophthalmia
Arthritis + Scleromalacia (softening/degeneration of sclera)