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Flashcards in Serology and Lab Testing - Johnston Deck (44)
1

Diagnostic labs for arthritis (7)

- RF
- Anti-CCP
- ANA
- ESR
- CRP
- ASOT (anti-streptolysin titer)
- Uric acid

2

RF + Anti-CCP = ____

RA (99.5% confidence)

3

ANA - means what alone?

Little - many people have them

4

ASOT - means what?

Previous streptococcal infection

5

List of acute phase reactants (7)

- ESR
- CRP
- Leukocytosis
- Thrombocytosis
- Ferritin
- Fibrinogen
- Complement

6

Which one is higher in women?

Also higher in who?

Diseases that this is especially good for? (2)

ESR

Older

Polymyalgia rheumatica, giant cell arteritis

7

CRP is a good marker for ___

Made where?

Does what?

Any inflammation (pro-inflammatory cytokines)

Liver

Activates complement, promotes phagocytosis

8

**CRP vs. ESR levels over time

CRP -- rises and falls faster than ESR

9

CRP > ___ = inflammatory

8

10

RF is MOST commonly what?

Produced by what?

IgM -- against Fc of IgG

B cells in synovial joints

11

Patients with _____ will 100% have RF antibodies

RA subQ nodules

12

Other autoimmune diseases that can have RF

Sjogrens, SLE, Cryoglobulinemia, Primary Biliary Cirrhosis, MCT disease, Endocarditis, Sarcoidosis, malignancy

13

Patients w/ RF are most likely to have what antibody?

Associated with?

Anti-CCP

Aggressive, erosive disease

14

Homogenous pattern of ANA immunofluorescence

Which ones? (3)

Drug-induced

Phenytoin, Procainamide, Hydralazine

15

Anti-Smith antibodies

SLE ONLY

16

Criteria for SLE (11)

Malar rash
Discoid rash
Photosensitivity
Oral/nasal ulcers - painless
Arthritis - 2+ peripheral joints
Serositis - pleuritis, pericarditis
Neurologic issue - seizure/psych
Renal issue - proteinuria or casts
***Blood disorder - HA + reticulocytosis, low WBC (under 4000), low platelets (under 100,000)
Immunologic issue - antibodies
ANAs

17

False positive RPR (test for syphilis)

SLE

18

ASO titer

Previous Group A strep infection

19

Acute rheumatic fever - criteria

JONES criteria
- Joints (arthritis)
- Carditis
- Nodules (subQ)
- Erythema marginatum
- Sydenham chorea

20

Digital radiography is good for looking at what?

Joint erosions, osteopenia, etc.

21

Ultrasonography is good for looking at what?



Aid in doing what?

Soft tissue abnormalities - synovitis, tendonitis, bursitis


Injecting/aspirating joint

22

MRI is good for what?

Don't use Gadolinium if...?

Soft tissue abnormalities - spine, SI, synovitis, tenosynovitis, erosions

Kidney disease - will cause nephrogenic systemic fibrosis

23

CT is good for what?

Bony abnormalities, erosions, fractures, degenerative or inflammatory arthritis

24

Pitting of nails

Psoriasis
Reactive arthritis

25

Balantitis

Reactive arthritis
Reiter's syndrome

26

Erythema migrans

Lyme disease

27

Erythema multiforme

Multiple causes

28

Erythema nodosum

Hepatitis, Mono, Syphilis, Strep
Other stuff

29

Discoid plaques on face

SLE

30

Inflamed gut + sores in mouth + sores in genitals

Behcet's disease

31

Reactive arthritis - bugs

Campylobacter
Salmonella
Shigella
Yersinia

32

Clubbing + arthritis + pulmonary disease

Hypertrophic pulmonary osteoarthritis (HPO)

33

Nodules in lungs + arthritis

RA, Wegeners, Paraneoplastic

34

Hilar nodes + arthritis

Sarcoidosis
RA
Lymphoma

35

Pulmonary infiltrates + arthritis

Septic
Wegeners

36

Charcot's joint

DM -- Neuropathic degeneration and distortion of a joint

37

Cheiroarthropathy

DM -- Thickened skin, limited joint mobility of hands and fingers, causing flexion contractures

38

Hypothyroidism can present with what?

Carpal/Tarsal Tunnel Syndrome

39

Arthritis + conjunctivitis

Seronegative spondyloarthropathies

40

Arthritis + iritis

SNSA, Lyme, JRA, Sarcoid

41

Arthritis + lacrimal enlargement

Sarcoid, RA

42

Arthritis + xerophthalmia

Sjogren's, Sarcoid

43

Arthritis + Scleromalacia (softening/degeneration of sclera)

RA

44

Arthritis + Episcleritis

RA