Flashcards in Session 5 Deck (10):
Broadly what in the main mechanism of action for antivirals?
Virostatic (virucidal only used topically occasionaly)
What are the different methods antivirals can inhibit viral replication?
Fusion/entry inhibitors, reverse transcriptase inibitors, integrase inhibitors, protease inhibitors
How do immunomodulator antivirals work?
Replace deficient host immunity (immunoglobulins)
Enhance host immunity (e.g. interferons, imiquimod)
What is the first line treatment for chronic hepatitis B?
48 week course of peginterferon alfa-2a
2nd line - Entecavir
What is the drug treatment for hepatitis C?
Peginterferon and ribavirin
Why are 3 different drugs often used for antiretroviral therapy?
They each affect a different step of the viral replication cycle making treatment more successful and reduces chance of resistance (often just one pill but 3 drugs inside)
Give examples of uses for prophylaxis of bacterial infections
Peri operative - prevention of surgical site infections
Short term - meningitis contacts
Long term - asplenia, immunodeficiency
What are the different types of antibiotic adverse effects?
Pharmacological - toxicities, drug interactions
Impact on normal flora e.g. Clostridium difficile
What antibiotics need to be monitored?