Session 5 Flashcards Preview

Pharmacology > Session 5 > Flashcards

Flashcards in Session 5 Deck (10):

Broadly what in the main mechanism of action for antivirals?

Virostatic (virucidal only used topically occasionaly)


What are the different methods antivirals can inhibit viral replication?

Fusion/entry inhibitors, reverse transcriptase inibitors, integrase inhibitors, protease inhibitors


How do immunomodulator antivirals work?

Replace deficient host immunity (immunoglobulins)
Enhance host immunity (e.g. interferons, imiquimod)


What is the first line treatment for chronic hepatitis B?

48 week course of peginterferon alfa-2a
2nd line - Entecavir


What is the drug treatment for hepatitis C?

Peginterferon and ribavirin


Why are 3 different drugs often used for antiretroviral therapy?

They each affect a different step of the viral replication cycle making treatment more successful and reduces chance of resistance (often just one pill but 3 drugs inside)


Give examples of uses for prophylaxis of bacterial infections

Peri operative - prevention of surgical site infections
Short term - meningitis contacts
Long term - asplenia, immunodeficiency


What are the different types of antibiotic adverse effects?

Pharmacological - toxicities, drug interactions
Allergic reactions
Impact on normal flora e.g. Clostridium difficile


What antibiotics need to be monitored?

Gentamicin (aminoglycoside)
Vancomycin (glycopeptide)


What are the general principles to prevent antibiotic resistance?

Prevent bacterial exposure to antibiotics - minimise risk of infection and control antibiotic prescribing
Preventing the spread of resistant bacteria - hand hygeine, isolation, decolonisation of patients