Flashcards in Session 5 Deck (10):
1
Broadly what in the main mechanism of action for antivirals?
Virostatic (virucidal only used topically occasionaly)
2
What are the different methods antivirals can inhibit viral replication?
Fusion/entry inhibitors, reverse transcriptase inibitors, integrase inhibitors, protease inhibitors
3
How do immunomodulator antivirals work?
Replace deficient host immunity (immunoglobulins)
Enhance host immunity (e.g. interferons, imiquimod)
4
What is the first line treatment for chronic hepatitis B?
48 week course of peginterferon alfa-2a
2nd line - Entecavir
5
What is the drug treatment for hepatitis C?
Peginterferon and ribavirin
6
Why are 3 different drugs often used for antiretroviral therapy?
They each affect a different step of the viral replication cycle making treatment more successful and reduces chance of resistance (often just one pill but 3 drugs inside)
7
Give examples of uses for prophylaxis of bacterial infections
Peri operative - prevention of surgical site infections
Short term - meningitis contacts
Long term - asplenia, immunodeficiency
8
What are the different types of antibiotic adverse effects?
Pharmacological - toxicities, drug interactions
Allergic reactions
Impact on normal flora e.g. Clostridium difficile
9
What antibiotics need to be monitored?
Gentamicin (aminoglycoside)
Vancomycin (glycopeptide)
10