Session 6 Flashcards

(18 cards)

1
Q

What is rheumatoid arthritis?

A

Autoimmune, multisystem disease. It initially localises to synovium, causing proliferation and subsequent dissolution of cartilage and bone

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2
Q

What are the clinical features of RA used for diagnosis?

A

At least 4 of the following
Morning stiffness for more than an hour most morning for 6 weeks
Arthritis of 3 or more joints (including a hand joint for extra point) for 6 weeks
Symmetrical arthritis
Rheumatoid nodules
Serum rheumatoid factor
X ray changes

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3
Q

What is the treatment strategy for RA?

A

Early diagnosis and early use of disease modifying antirheumatic drugs (DMARDs)
Avoidance of long term corticosteroids

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4
Q

What are the treatment goals in SLE and vaculitis?

A

Symptomatic relief (e.g. arthralgia, Raynaud’s), reduction in mortality and long term morbidity, prevention of organ damage

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5
Q

What is the mechanism of action for corticosteroids?

A

Prevent interleukin (IL)-1 and IL-6 production by macrophages. Inhibit all stages of T cell activation.

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6
Q

What is the first line treatment for RA?

A

Two DMARDs and one short term glucocorticoid

E.g. methotrexate, sulfasalazine and prednisolone

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7
Q

Why are TPMT levels checked before prescribing azathioprine?

A

TPMT metabolises the drug - if low TPMT levels are present there is a risk of myelosupression

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8
Q

What is the pathophysiology of asthma?

A

Smooth muscle dysfunction - increased contraction and cytokines
Airway remodeling - mucous gland hyperplasia, subepithelial fibrosis, epithelium desquamation, wall thickening
Inflammation - T cells, mast cells, eosinophils

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9
Q

Give an overview of the stepwise therapy of asthma in adults

A

1 - mild intermittent asthma, SABA (move up if 3 or more per week)
2 - regular preventor therapy, add low dose ICS
3 - add on therapy, add LABA, then increase ICS dose
4 - persistent poor control, high ICS dose, add 4th drug
5 - oral steroids or biological therapies (anti-IgE)
Step down recommended after control

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10
Q

What are indications of good asthma control?

A

Minimal symptoms during day and night, minimal need for reliever medication, no exacerbations, no limitation of physical activity, normal lung function (FEV1 and PEF)

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11
Q

What steps should be taken before initiating a new asthma drug therapy?

A

Check compliance with existing therapies, check inhaler technique, eliminate trigger factors

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12
Q

Outline the drugs used and mechanism of action for step 1 asthma therapy

A

Short acting beta2 agonist - salbutamol or terbutaline
Used for symptom relief through reversal of bronchoconstriction. If used regularly they reduce asthma control (mast cell degranulation in response to allergen increases).

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13
Q

When should a patient be stepped up from step 1 to step 2?

A

Using SABA 3 or more times a week
Symptoms 3 or more times a week
Waking 1 or more times a week
Consider if exacerbation requiring oral steroids in last 2 years

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14
Q

What are the benefits of inhaled corticosteroids in asthma?

A

Improve symptoms and lung function, reduce exacerbations and prevents death

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15
Q

What are alternative step 3/4 add on drugs?

A

Leukotriene receptor antagonists (LTRA) - montelukast
Theophylline - adenosine receptor antagonist
Tiotropium - long acting anticholinergic (LAMA)

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16
Q

What is acute severe asthma?

A

One of: unable to complete sentences, HR greater than 110, RR greater than 25, peak flow 33-50% best or predicted

17
Q

What is the treatment of acute severe asthma?

A

High flow O2 to keep sats 94-98%
Nebulised salbutamol
Oral prednisolone for 10-14 days Add IV hydrocortisone if very ill
If fails - nebulised ipratropium bromide (anticholinergic) or IV aminophylline (same class as theophylline). Add magnesium sulfate if life threatening

18
Q

What are features of life threatening asthma?

A

PEF less than 33%, sate less than 92, PaO2 less than 8kPa, PaCO2 greater than 4.5 kPa (greater than 6 requires mechanical ventilation), silent chest, cyanosis, feeble respiratory effort, hypotension, bradycardia, confusion, coma