Shit - Heme UWorld Flashcards Preview

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Flashcards in Shit - Heme UWorld Deck (46):
1

Erb-B2

Her-2-nu

Ab = trastuzumab

2

Fibrin selective thrombolytic:

vs.

non-selective:

Selective = tPA, alteplase, reteplase, tenecteplase

 

Non-selective = streptoknase, urokinase

3

Which cancer creates a tyrosine kinase fusion protein

CML: bcr-abl

Rx = imatinib (binds TK)

4

enoxaparin, dalteparin, fondaparinux

LMWH

binds AT-III promoting Xa inactivation

5

Prothrombin

Factor II

6

PNH triad

Pancytopenia: acquired stem cell mutatoin, so other lineages mutated too; can also be aplastic anemia

Negative coombs HA: loss of GPI anchor, so no CD55 or CD59 to inhibit MAC

Vanous thromboses (i.e. budd-chiari): prothrombotic factors released from lysed RBCs and platelets

7

Reed-sternberg = 

HODGKINS

8

yellow-brown pigment = 

lipofuscin OR hemociderin

9

Cytic AND solid brain tumour in kids

Pilocytic astrocytoma

10

Lung cancer with neuroendocrine markers 

(synaptophysin, chromogranning, neurofilaments, neuron-specific enolase

11

Prolonged PTT but normal PT and thrombin time = deficiency in:

VIII, IX, XI, or XII

12

von Willibran disease inheritance

AD with variable penetrance

13

increased bleeding time indicates:

platelet problem

14

Cox -1 vs Cox- 2 funcitons/AE

Cox-1 blocks TXA-2, so prevents clots/causes bleeding; also blocks PG-I

 

Cox-2 blocks PGs (and PG-I only wrt blood sutff), so anti-inflammatory but pro-coagular/anti-bleeding

15

CCl4 causes

free-radical damage

16

Dysplasia vs carcinoma?

reversibility

17

MC location of cancer in LiFraumeni

breast, brain, adrenal cortex, sarcomas, leukemias

18

Angiogenesis GFs

VEGF (can be stimulated by IL-1 and IFN-g)

FGF

19

Aplastic anemia classic signs

BM: hypocellular with fatty replacement and stroma

Spleen: NO splenomegaly to complensate (because stem cell problem)

20

Non-truma foot/wrist drop

Churg strauss

Lead poisoning

21

Shortest t1/2 of CFs and result

VII

In liver problems, PT is first thing to be elevated

(most CFs made in liver)

22

vincrinstine AE

neurotoxicity: tingling in fingers and toes (peripheral neuropathy)

23

leucovirin

aka folinic acid

THF derivative that doesnt need DHF-reductase to be activated

Rescure for BM suppression, mucositis, GI problems

24

infliximab

Anti-TNF-a

25

rituximab

MAb-CD20

26

cancer with altered PDGF

chronic myelomonocytic leukemia

27

Protein C resistance

Factor V leiden mutation

28

Functions of the genes in cancer translocations:

- 8;14

- 14;18

- 11;14

- 9;22

- 15;17

- 8;14: 8 = c-myc = TC activator = burkitts

- 14;18: 18 = bcl-2 = blocks apoptosis = follicular

- 11;14: 11 = cyclin D1 = cell cycle regulator = mantle cell

- 9;22: 22 = abl = tyrosine kinase (cyto + nuc) = CML

- 15;17: 15 = RAR = myelocyte differentiation = PAML

29

30

glucose and heme synthesis

glucose inhibits ALA-synthase

Rx for AIP

(also blocked by heme)

31

painless waxing and waning LAD

follicular lymphoma

32

cachexia hormone

TNF-a (cachexin)

33

microsomal monooxygenase

= CYP450

Overexpression converts more pro-carcinogens to carcinogens, increasing risk of cancer

34

kid with blasts in periphery with trouble breathing and swallowing

T-ALL via mediastinal thymic mass

35

Raltegravir

Prevents integration, thus host from making virus mRNA

36

hematology drug causeing neutropenia presenting as fever and mouth ulcers

Ticlopidine (ADP-R blocker)

 

use only if allergic to asprin + clopidogrel

37

PE:

acute management

vs

longterm prevention DOC

Acute = herparin

 

longterm = warfarin

38

lymphocytosis + low ALP

CML

39

P glycoprotein mechanism

ATP-dependent transporter

in bacteria and cancer cells

40

PUre recc cell aplasia: causes

IgG of CD8 against erythroid precursors/progenitors.

Often linked to thymomas and lymphocytic leukemias 

41

why do pregnancy catastrophies cause DIC?

Thromboplastin (TF/CF III) released from placenta

42

Hemolysis in G6PD

INH, sulfonamides, dapsone, asprin, ibuprofen, primaquine, nitrofurantoin

43

most important prognostic factor

STAGE = TMN (alnd invasion)

(NOT grade = level of differentiation)

44

Myeloperoxidase +ve leukemia

AML

(also see auer rods, these are what stain)

45

Isolated increase in BT

Bernard soulier (no GpIb)

ASA (decrease TXA2)

Uremia (platelets to aggregate/adhere properly)

46

cisplatin/carboplatin nephrotoxicity rescue

Amifostine and chloride saline diuresis