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Jenna's Shit List > Shit - Heme UWorld > Flashcards

Shit - Heme UWorld Flashcards

(46 cards)

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1
Q

Erb-B2

A

Her-2-nu

Ab = trastuzumab

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2
Q

Fibrin selective thrombolytic:

vs.

non-selective:

A

Selective = tPA, alteplase, reteplase, tenecteplase

Non-selective = streptoknase, urokinase

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3
Q

Which cancer creates a tyrosine kinase fusion protein

A

CML: bcr-abl

Rx = imatinib (binds TK)

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4
Q

enoxaparin, dalteparin, fondaparinux

A

LMWH

binds AT-III promoting Xa inactivation

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5
Q

Prothrombin

A

Factor II

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6
Q

PNH triad

A

Pancytopenia: acquired stem cell mutatoin, so other lineages mutated too; can also be aplastic anemia

Negative coombs HA: loss of GPI anchor, so no CD55 or CD59 to inhibit MAC

Vanous thromboses (i.e. budd-chiari): prothrombotic factors released from lysed RBCs and platelets

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7
Q

Reed-sternberg =

A

HODGKINS

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8
Q

yellow-brown pigment =

A

lipofuscin OR hemociderin

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9
Q

Cytic AND solid brain tumour in kids

A

Pilocytic astrocytoma

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10
Q

Lung cancer with neuroendocrine markers

A

(synaptophysin, chromogranning, neurofilaments, neuron-specific enolase

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11
Q

Prolonged PTT but normal PT and thrombin time = deficiency in:

A

VIII, IX, XI, or XII

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12
Q

von Willibran disease inheritance

A

AD with variable penetrance

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13
Q

increased bleeding time indicates:

A

platelet problem

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14
Q

Cox -1 vs Cox- 2 funcitons/AE

A

Cox-1 blocks TXA-2, so prevents clots/causes bleeding; also blocks PG-I

Cox-2 blocks PGs (and PG-I only wrt blood sutff), so anti-inflammatory but pro-coagular/anti-bleeding

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15
Q

CCl4 causes

A

free-radical damage

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16
Q

Dysplasia vs carcinoma?

A

reversibility

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17
Q

MC location of cancer in LiFraumeni

A

breast, brain, adrenal cortex, sarcomas, leukemias

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18
Q

Angiogenesis GFs

A

VEGF (can be stimulated by IL-1 and IFN-g)

FGF

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19
Q

Aplastic anemia classic signs

Study These Flashcards
A

BM: hypocellular with fatty replacement and stroma

Spleen: NO splenomegaly to complensate (because stem cell problem)

20
Q

Non-truma foot/wrist drop

Study These Flashcards
A

Churg strauss

Lead poisoning

21
Q

Shortest t1/2 of CFs and result

Study These Flashcards
A

VII

In liver problems, PT is first thing to be elevated

(most CFs made in liver)

22
Q

vincrinstine AE

Study These Flashcards
A

neurotoxicity: tingling in fingers and toes (peripheral neuropathy)

23
Q

leucovirin

Study These Flashcards
A

aka folinic acid

THF derivative that doesnt need DHF-reductase to be activated

Rescure for BM suppression, mucositis, GI problems

24
Q

infliximab

25
rituximab
MAb-CD20
26
cancer with altered PDGF
chronic myelomonocytic leukemia
27
Protein C resistance
Factor V leiden mutation
28
Functions of the genes in cancer translocations: - 8;14 - 14;18 - 11;14 - 9;22 - 15;17
- 8;14: 8 = c-myc = TC activator = burkitts - 14;18: 18 = bcl-2 = blocks apoptosis = follicular - 11;14: 11 = cyclin D1 = cell cycle regulator = mantle cell - 9;22: 22 = abl = tyrosine kinase (cyto + nuc) = CML - 15;17: 15 = RAR = myelocyte differentiation = PAML
29
30
glucose and heme synthesis
glucose inhibits ALA-synthase Rx for AIP (also blocked by heme)
31
painless waxing and waning LAD
follicular lymphoma
32
cachexia hormone
TNF-a (cachexin)
33
microsomal monooxygenase
= CYP450 Overexpression converts more pro-carcinogens to carcinogens, increasing risk of cancer
34
kid with blasts in periphery with trouble breathing and swallowing
T-ALL via mediastinal thymic mass
35
Raltegravir
Prevents integration, thus host from making virus mRNA
36
hematology drug causeing neutropenia presenting as fever and mouth ulcers
Ticlopidine (ADP-R blocker) use only if allergic to asprin + clopidogrel
37
PE: acute management vs longterm prevention DOC
Acute = herparin longterm = warfarin
38
lymphocytosis + low ALP
CML
39
P glycoprotein mechanism
ATP-dependent transporter in bacteria and cancer cells
40
PUre recc cell aplasia: causes
IgG of CD8 against erythroid precursors/progenitors. Often linked to thymomas and lymphocytic leukemias
41
why do pregnancy catastrophies cause DIC?
Thromboplastin (TF/CF III) released from placenta
42
Hemolysis in G6PD
INH, sulfonamides, dapsone, asprin, ibuprofen, primaquine, nitrofurantoin
43
most important prognostic factor
STAGE = TMN (alnd invasion) | (NOT grade = level of differentiation)
44
Myeloperoxidase +ve leukemia
AML (also see auer rods, these are what stain)
45
Isolated increase in BT
Bernard soulier (no GpIb) ASA (decrease TXA2) Uremia (platelets to aggregate/adhere properly)
46
cisplatin/carboplatin nephrotoxicity rescue
Amifostine and chloride saline diuresis

Jenna's Shit List (23 decks)

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