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Flashcards in Shit - Resp UWorld Deck (40):
1

Exercise on arterial and venous values

Arterial normal; venous altered

2

CTFR mutation causes

altered post-translational processing of ATP-bincdin-cassette transmembrane Cl- transporter

3

Cheyne-Stokes causes and patters

CHF
Neuro (stroke, brain tumour, TBI)

Delayed response and increased sensitivity to PCO2

4

Theophylline OD

Abdominal pain, vomiting, diarrhea; seizures (high M+M), arrhythmia (Rx = b-blockers)

5

why does hyperventilation cause dizziness?

Decreased PCO2 so body thinks you have high PO2 so cerebral vessels constrict in auto regulation to prevent "intracranial HTN". VC decreases BF causing dizziness, blurred vision, weakness

6

MOA chronic bronchitis vs. emphysema

CB = narrowed airways, less air thru. Emph = dilates alveoli; decreased ability of deoxygenated blood in vessels to contact the air in the alveoli

7

Dyspnea with dry cough, insidious, sub pleural cysts, restrictive pattern =

Idiopathic/usual progressive pulmonary fibrosis

8

honeycomb lung =

indiopathic/usual progressive pulmonary fibrosis

9

What are mycelia acids

Long, branched, saturated FAs

10

true vs false vocal cord linings

true = start squam. false (and vestibule) = respiratory.

11

drug that needs activation by catalase-peroxidase

INH

12

where is rRNA transcribed, and by what?

Nucelolus; RNA pol-I

13

aspiration pneumonia via what (where from body and bugs)

oropharynx.

fusobacterium, peptostreptococcus, bacteroides

14

eggshell calcifications and birefringent crystals

silicosis

15

coal macules

Macrophages full of carbon

16

INH AE

Neurotoxicity (peripheral neuropathy (rx by B6), hepatotoxicity, sideroblastic anemia, SLE-like

17

Quitting smoking drugs

Bupropion, varenicline (partial agonist)

18

tissue destruction in MTB mediated by:

hypersensitivity reaction

19

Probability of kid getting AR disease =

Parent carrier % x parent carrier % x 1/4

20

Baro-R vs chemo-Rs: names and what they respond to

Peripheral:
Aortic arch and carotid sinus = BP
Carotid body and aortic body = O2 (CO2, H+)

Central:
Medulla = CO2 (via H+/pH)

21

pulmonary C-fibres

= stretch receptors; prevent lung over-inflation

22

what causes pus to be green?

Myeloperoxidase from neutrophil azurophilic granules

23

MAC (vs MTB): s/s, host, prophylaxis

MAC:
s/s = like TB, but also hits reticuloendothelial system so anemia, hepatosplenomegally, high LDH, high ALP. Also grows best @41C (MTB doesn't).
Host = HIV CD4

24

Nerve near piriform recess

internal branch of superior laryngeal n = afferent of gag reflex

25

A-a calculation

150 - PaCO2/0.8

26

Why would a kid with CF present with signs of hedydration?

Excessive sweating, leads to SODIUM loss (not water), which causes an intravascular volume contraction

27

MTB drugs that works at acidic pH?

Pyrazinamide: works in INTRAcellular (within macrophage)) MTB, because it works best in acidic environments like the phago-lysosome

28

where is airflow resistance highest in the lungs and why

sections 2-5 because of turbulent flow [so resistance increases then drastically decreases as you do down the lung divisions]

29

neutrophil chemotaxis via:

C5a, LTB4, IL-8, 5-HETE (LT precursor)

30

Atelectasis

collapse of lung (can be partial, i.e. ARDS)

31

Pancoast tumour vs. SVC syndrome

Pancoast has SVC syndrome as a component, but also has horners and shoulder pain and hoarseness due to apical location.

SVC syndrome can occur with a mediastinal mass, thus blocks SVC but is NOT found in apex so no horners or shoulder pain. MCC = lung cancer and NHL

32

mesothelioma histology

long thin microvilli with lots of tonofilaments

33

pathophysiology of high ESR

Injury --> neutrophils and macrophages ---> release TNF-a, IL-1, IL-6 -> cause liver to release acute phase reactants --> one of them is fibrinogen --> RBC rouleaux --> faster sedimentation than normal (individual) RBCs

34

Pancoast tumour pain dermatomes

C8, T1, T2

35

size of particles (URT vs cilia vs dust cells)

URT = 10-15 nm.
cilia = 2.5-10nm.
dust =

36

LTs in asthma

C4, D4, E4

37

Scleroderma + CREST and lung problems

pulmonary arterioles damages --> pulmonary HTN, loud S2 (increased back pressure on pull valve), and signs of RHF

38

Capillary wedge pressure in ARDS

NORMAL! Non-cariogenic cause of pulmonary edema

39

Compliance in ARDS

Decreased

40

Decreased compliance caused by:

pulmonary fibrosis, insufficient surfactant, pulmonary edema