Flashcards in Sickle cell Deck (9)
SS disease is AR/AD?
SSD disease of what gene?
beta globin gene - glu-> val
When do RBC sickle?
deoxygenated, after many cycles, remains sickle -> removed by splene
Differentiate SS trait, SS disease, and SS cell anemia
SS trait = S + A(normal)
SSD = S + X (not normal, beta 0, beta +, C)
SS cell = S + S
Asian sickle cell gene vs african
aa/-- vs a-/a-
CBC of sickle cell disease
sickle cell; SC, SB thals
Howell-Jolly --> DNA/RNA cannot be removed by spleen
Target cells and Hbg Cyrstals in SC disease
Target + microcytosis in SB0 or SB + thal
generally no consequence in Hct, Hgb, ret, size, and clinical severity
Rarely - hypoxic stress
Name all type of sickle cell disease/traits from most severe to lease
SS/SB0; SB+, SC; AS