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Flashcards in Sickle cell Deck (9)
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1

SS disease is AR/AD?

AR

2

SSD disease of what gene?

beta globin gene - glu-> val

3

When do RBC sickle?

deoxygenated, after many cycles, remains sickle -> removed by splene

4

Differentiate SS trait, SS disease, and SS cell anemia

SS trait = S + A(normal)
SSD = S + X (not normal, beta 0, beta +, C)
SS cell = S + S

5

Asian sickle cell gene vs african

aa/-- vs a-/a-

6

CBC of sickle cell disease
sickle cell; SC, SB thals

Howell-Jolly --> DNA/RNA cannot be removed by spleen
Target cells and Hbg Cyrstals in SC disease
Target + microcytosis in SB0 or SB + thal
Sickle cell

7

Sickle trait

generally no consequence in Hct, Hgb, ret, size, and clinical severity

Rarely - hypoxic stress

8

Name all type of sickle cell disease/traits from most severe to lease

SS/SB0; SB+, SC; AS

9

Sickle cell disease therapies

Folate, penicilin, bone marrow transplantation, hydroxyurea, transfusion therapy