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Flashcards in Hematopoiesis Deck (31)
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1

Embryonal stage production in _______

yolk sac

2

Fetal stage (___ -____ months) in _____

2-7 mo, liver, spleen

3

Early childhood production in ____

long bones --> transitions to axial bones by teens

4

Axial bones include ___, ___, ___, ___, ____

vetebrae, pelvis, sternum, ribs, skull

5

Hematopoietic stem cells --> _________ cells --> _________ cells --> Mature cells

progenitor cells; precursors

6

lymphoid includes

T cells, B cells, NK cells, and precursors

7

Myeloid cells includes

Non-erythroid/non - lymphoid linages from marrow; Often (granulocytes, monocytes), megakaryocytes, platelets

8

Life span of erythrocytes

120 days

9

Pluripotential stem cell can make _________, and _______

self renewal (daughter self); progenitor cells

10

Pluripotential stem cells includs (CFU-X)____ and ____

CFU-GEMM and CFU-L
(granulocytes/erthroid, monocytes, megakaryocyte); Lymphoids
CFU = colony forming units

11

Progenitor cells are ____committed to differentiate along one or at most two linages

irreversibly

12

CFU - GM

CFU granulocyte/macrophage

13

CFU - M

monocyte

14

CFU-E

Erthroid

15

CFU-Meg

megakaryotes

16

CFU-Eo and Baso

eosinophil/basophil

17

BFU - E

Burst forming unit - erthyroid --> CFU - E

18

Precursor cells are:

recognizable, maturing cells, can divide but not self renew

19

Which cells can "self renew" and divide?

Hematopoietic stem cells, (multi-pluri potential stem cells), progenitor cells

20

RBC hematopoiesis lineage from precursor

pronormoblast --> basophilic normoblast --> polychromatophilic normao blast --> orthochromatic normoblast (no replicate) --> Reticulocyte -> erythrocyte

21

Pyknosis/karyopyknosis is ____________?

irreverisble condensation of chromatin

22

Granulocyte maturation lineage from precursor

myeloblast --> promyeloctye --> metamyelocyte --> band --> segmented granulocytes (segs0

23

platelet formation lineage from precursor

megakaryoblast --> promegakaryocyte --> megakaryocyte --> platelet

24

Macrophage linage

monoblast --> promonocyte --> monocyte --> in tissues = macrophage

25

HFG (hematopoietic growth factors - 7)

a. Erythropoietin (EPO) kidney to hypoxia  promotes erthyropoeisis
b. Thrombopoietin (TPO) – promotes megakaryopoiesis
c. Granulocyte-monocyte colony stimulating factor (GM-CSF) promotes granulopoiesis and monopoiesis
d. Granulocyte colony stimulating factor (G-CSF) promotes granulopoiesis
e. Monocyte colony stimulating factor (M-CSF) – monopoiesis
f. Interleukin 5 (IL-5) – promote production with eosinophils
g. Interleukin 3 (IL-3) – promotes production of basophils

26

Life span of PMN

7 hours

27

Life span of platelets

8.5 days

28

marrow cellularity by age

100-age

29

Hyperplastic marrow cellularity

increase proliferation of one or more lineages

30

Aplastic marrow - define and cause

Marrow not there; autoimmune, viral (parvovirus B19), hematopoietic neoplasm, malnourished